What Is 2-(4-Fluorophenyl)-thiophene CAS 58861-48-6? Properties, Uses, and Supplier Information

2-(4-Fluorophenyl)-thiophene, identified by CAS No. 58861-48-6, is a fluorinated thiophene building block used primarily in organic synthesis and research. Its structure combines a thiophene ring with a para-fluorophenyl group, giving chemists a sulfur-containing heteroaromatic framework and a strategically positioned fluorine substituent. The commonly assigned molecular formula is C₁₀H₇FS, with a calculated molecular weight of approximately 178.23 g/mol. I recommend treating it as a research and intermediate material rather than assuming a single fixed end use, because the appropriate specification depends on the downstream synthesis, analytical method, and scale.

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For purchasing, the most important checks are identity, assay, impurity profile, water content, residual solvents, packaging, and available supply quantity. Maison Chemical can support B2B buyers by reviewing the intended application, confirming the required specification, and coordinating documentation before an order is finalized. Where a public source does not establish a physical property or performance value, I recommend verifying the current batch-specific certificate of analysis instead of relying on an assumed value.

Definition and Chemical Identity

2-(4-Fluorophenyl)-thiophene is an unsymmetrical aromatic compound containing one thiophene ring and one fluorinated benzene ring. The thiophene portion contains sulfur as a heteroatom, while the fluorophenyl portion contains fluorine in the para position relative to the bond connecting the two rings. This arrangement is relevant to synthetic chemists because both the heteroaromatic ring and the aryl fluoride can influence subsequent molecular design.

The compound is generally described as a neutral, low-molecular-weight organic intermediate. Its molecular weight is approximately 178.23 g/mol, and its molecular formula is commonly represented as C₁₀H₇FS. These identity data should be matched against the supplier’s analytical documentation, such as a certificate of analysis and an appropriate chromatographic or spectroscopic test, before use in a regulated or tightly controlled project.

Core Functions in Chemical Synthesis

Heteroaromatic Building Block

The primary role of this material is to provide a preassembled thiophene–fluorophenyl motif for further synthesis. Thiophene-containing fragments are frequently considered during the design of advanced organic molecules because they offer a compact aromatic structure with sulfur-based heteroatom functionality. The fluorinated phenyl group can also be retained as part of the final molecule or used as a substituent that affects molecular properties.

Intermediate for Molecular Design

In a synthetic route, 2-(4-Fluorophenyl)-thiophene may serve as an intermediate for preparing more complex aromatic or heteroaromatic compounds. The exact reaction pathway depends on the functional groups introduced in later steps and on the customer’s target structure. I therefore avoid presenting this CAS number as a finished pharmaceutical ingredient or as a material with one guaranteed biological function.

Potential Application Scenarios

This compound may be evaluated in medicinal chemistry, pharmaceutical intermediate development, materials research, and academic or industrial organic synthesis. In medicinal chemistry, a fluorinated thiophene fragment can be incorporated into candidate molecules during structure–activity relationship studies, subject to the project’s own biological and regulatory evaluation. In materials-oriented research, thiophene derivatives may be investigated as components of larger conjugated systems, although suitability must be established through the specific molecular design and performance testing.

It may also be useful for route scouting and process development. A buyer can use the material to compare reaction conditions, assess impurity formation, or prepare a larger downstream intermediate. These uses are application possibilities rather than guarantees; performance depends on reaction chemistry, purity, equipment, scale, and the quality requirements of the final product.

Properties and Material Options

The most reliable starting point is the compound’s chemical identity: CAS No. 58861-48-6, formula C₁₀H₇FS, and approximate molecular weight 178.23 g/mol. Appearance, melting behavior, water content, and exact purity should be confirmed from the current product specification or batch certificate because these values can vary with manufacturing, purification, storage, and test method. A product page or quotation should not replace batch-specific documentation when the material is used in a controlled synthesis.

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The table provides an initial identification framework, not a substitute for a specification sheet. For example, an assay target of 98% or higher may be suitable for some research applications, while a process route may require tighter control of regioisomers, unreacted starting materials, metals, water, or residual solvents. I recommend asking for the test method, not only the numerical result, because analytical values are meaningful only when the method and reporting basis are clear.

Key Specifications to Request

Identity and Assay

Ask the supplier to confirm the CAS number, molecular formula, molecular weight, and product name on the quotation and certificate of analysis. Identity testing may include methods such as nuclear magnetic resonance, mass spectrometry, infrared analysis, or chromatography, depending on the supplier’s quality system and the customer’s requirements. The buyer should confirm that the analytical identity is consistent with the proposed structure and intended reaction.

Impurity and Stability Information

For route development, the impurity profile can be as important as the headline assay. Relevant questions may include whether related aromatic compounds, starting materials, regioisomers, inorganic residues, water, and residual solvents are tested or controlled. Storage conditions should be based on the supplier’s safety data sheet and packaging recommendation; buyers should keep the container tightly closed, protect it from incompatible conditions, and follow the stated handling instructions.

Packaging and Documentation

Request a certificate of analysis, safety data sheet, product specification, batch or lot identification, net weight, and recommended storage information. If the material is intended for export, confirm the shipping classification and documentation requirements before dispatch. Packaging should be selected according to order size, chemical compatibility, moisture sensitivity if applicable, and the buyer’s internal receiving procedures.

How Buyers Should Select a Supplier

I recommend evaluating a supplier on more than price. First, confirm that the supplier can provide the exact CAS number and a traceable batch document. Next, compare assay, impurity limits, test methods, packaging, lead time, minimum order quantity, and communication speed. Finally, check whether the supplier can support repeat orders with consistent specifications rather than treating every purchase as an isolated spot transaction.

• Identity control: Confirm CAS No. 58861-48-6 and the stated molecular formula.
• Quality documentation: Request a current COA and SDS before purchase approval.
• Specification fit: Match assay and impurity limits to the downstream reaction.
• Supply planning: Clarify sample availability, production lead time, MOQ, and pack sizes.
• Technical communication: Ask whether the supplier can review special analytical or packaging needs.

Maison Chemical Supplier Support

Maison Chemical supplies chemicals and pharmaceutical intermediates for business customers seeking dependable sourcing support. For 2-(4-Fluorophenyl)-thiophene, I can help organize the initial technical review around the customer’s intended use, required assay, order quantity, delivery location, and documentation needs. This approach reduces the risk of selecting a material that meets a catalogue description but does not match the buyer’s process specification.

For development projects, buyers may need a small evaluation quantity before committing to a larger order. For production planning, they may instead require a supply schedule, defined packaging, repeat-batch documentation, and clear acceptance criteria. Availability, MOQ, price, and lead time should be confirmed by quotation because they depend on quantity, specification, destination, and current production status.

Summary Insight

2-(4-Fluorophenyl)-thiophene CAS 58861-48-6 is a fluorinated thiophene building block with an approximate molecular weight of 178.23 g/mol and the commonly assigned formula C₁₀H₇FS. Its main value is as a versatile intermediate for organic synthesis, medicinal chemistry research, and selected materials-development programs. The material should not be treated as a finished active pharmaceutical ingredient without project-specific evidence and regulatory evaluation.

The practical next step is to send Maison Chemical your target quantity, required assay, application, destination, and documentation expectations. I can then help you compare the available specification, packaging, MOQ, lead time, and commercial terms. A clear technical request at the beginning gives both sides a stronger basis for selecting and supplying the right grade.

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