4-Hydroxyphenylboronic Acid CAS 71597-85-8: Properties, Uses, and Sourcing Guide

4-Hydroxyphenylboronic acid, also called 4-(hydroxy)phenylboronic acid or 4-boronophenol, is an aromatic boronic acid used mainly as a building block in palladium-catalyzed cross-coupling and other boron-mediated synthesis routes. Its key identifying information is CAS 71597-85-8, molecular formula C₆H₇BO₃, and molecular weight approximately 137.93 g/mol. I recommend evaluating this material by identity, assay, water content, physical form, packaging, and batch-specific documentation rather than relying only on the product name.

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This guide explains the compound’s chemical features, common research and manufacturing applications, handling considerations, and the main factors buyers should review before placing an order. Because specifications can vary between suppliers and production batches, I use conservative language where a property must be confirmed by a current certificate of analysis.

Who This Guide Is For

This guide is intended for research chemists, process development teams, pharmaceutical and agrochemical intermediate buyers, material-science laboratories, and procurement professionals sourcing organic boronic acids. It is especially relevant when a project requires a para-hydroxy-substituted aryl boronic acid for laboratory synthesis or route development. The information also supports distributors who need a clear technical basis for comparing supplier quotations.

It is not a substitute for a product-specific safety data sheet, analytical method, or process hazard assessment. Before production use, I recommend reviewing the supplier’s latest specification, SDS, CoA, and handling recommendations for the exact batch being purchased.

Basic Chemical Context and Properties

Identity and Structure

4-Hydroxyphenylboronic acid contains an aromatic benzene ring bearing two para-position functional groups: a phenolic hydroxyl group and a boronic acid group. The boronic acid functionality can participate in reversible interactions with suitable diols and can also serve as a coupling partner in carbon–carbon bond-forming chemistry. The phenolic group provides an additional reactive handle that may influence solubility, protection strategies, and downstream reaction planning.

The molecular weight is useful for calculating reaction equivalents and preparing laboratory solutions. However, it should not be used as the only identity check because related boronic acid derivatives, hydrates, and oxidation products may have different analytical profiles. I advise confirming identity using the supplier’s stated analytical methods, which may include NMR, HPLC, LC-MS, or other techniques appropriate to the product specification.

Solubility, Stability, and Handling

Solubility can vary considerably with solvent, concentration, temperature, and pH. Buyers should not assume complete dissolution in water or any specific organic solvent without checking application data or conducting a small-scale compatibility test. In many synthesis workflows, the selected solvent system and base are important variables because the boronic acid can interact with water, bases, diols, and other polar components.

As with many boronic acids, storage should minimize unnecessary exposure to moisture, heat, and contamination. The appropriate temperature and packaging depend on the supplier’s stability assessment and product specification, so I recommend following the current SDS and CoA rather than applying a universal storage rule. A practical procurement specification may include a closed container, suitable moisture protection, lot traceability, and a defined retest or review date where applicable.

Types, Grades, and Specification Options

Most buyers encounter 4-hydroxyphenylboronic acid as a research or synthesis-grade solid. The term “grade” is not always standardized across suppliers, so the actual specification should be read carefully. One supplier may focus on assay and appearance, while another may provide a broader impurity profile, residual solvent information, water content, and analytical spectra.

Specification Points to Compare

• Assay: Commercial listings may show a target such as 98% or higher, but the accepted value should be confirmed in the current CoA.
• Identity: Review the analytical technique and acceptance criteria used to confirm the material.
• Impurities: Ask whether related aryl compounds, oxidized boron species, residual solvents, or inorganic residues are controlled.
• Water content: This may affect weighing, reaction concentration, and reproducibility.
• Particle and physical form: Powder characteristics can influence sampling, transfer, and dissolution.
• Packaging: Moisture-resistant primary packaging and clear lot labeling are important for repeated laboratory or manufacturing use.

For a screening project, a standard research specification may be sufficient. For a regulated or scale-up project, I would normally request a more detailed specification before approval, including analytical methods, impurity limits, change-control expectations, and sample retention practices. If the compound will be used as a starting material for a sensitive route, the buyer should also define whether trace metals or specific elemental impurities require control.

Application Matching

Synthetic Chemistry and Cross-Coupling

The principal application of 4-hydroxyphenylboronic acid is as an aryl boronic acid building block. It is commonly considered for Suzuki–Miyaura coupling with suitable aryl or vinyl halides and related electrophiles, subject to catalyst, base, solvent, and substrate compatibility. The para-hydroxy substituent can be retained in the product or protected before coupling when the reaction sequence requires different chemoselectivity.

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This material may also be useful in medicinal chemistry and intermediate development where a phenolic aryl fragment is required. The exact value depends on the target structure and route design; a successful reaction with one substrate does not guarantee the same performance with another. I recommend a small reaction screen that compares catalyst loading, base, solvent, temperature, and protection strategy before committing to a larger purchase.

Research, Materials, and Derivative Preparation

The boronic acid and phenolic functionalities can support preparation of more complex intermediates, functional molecules, and exploratory sensing or materials-related compounds. These uses are application-dependent and should be treated as research possibilities rather than guaranteed performance claims. Buyers should define the required downstream transformation and select the specification according to the sensitivity of that transformation.

Buyer Selection Framework

Step 1: Define the Required Quality Level

First, determine whether the material is needed for route scouting, analytical research, process development, or commercial manufacturing. Route scouting may prioritize availability and reasonable assay, while process development usually requires stronger lot consistency and more complete documentation. I recommend documenting the minimum assay, impurity limits, water limit, packaging, and analytical evidence before requesting quotations.

Step 2: Match Quantity to the Project

Purchase quantity should reflect the number of experiments, expected reaction yield, sampling needs, and potential repeat work. Small packages can reduce initial inventory risk, but larger quantities may improve continuity when a route has been validated. Since MOQ and package sizes differ by supplier, buyers should request both the available standard pack and a quotation for the planned annual or project volume.

Step 3: Evaluate Commercial Terms

Pricing for 4-hydroxyphenylboronic acid depends on assay, pack size, manufacturing route, order quantity, documentation, and shipping requirements. I do not recommend using an unverified market price as a purchasing benchmark because quotations can change with raw-material availability and quality requirements. Ask for price breaks, MOQ, lead time, sample availability, payment terms, export documentation, and the validity period of the quotation.

Lead time should be confirmed for the actual lot rather than assumed from an online catalog status. Stock material, production material, and customized material may have very different delivery schedules. If continuity is important, request a supply plan, production-batch information where available, and an agreed process for notifying customers about material or specification changes.

Supplier Evaluation Checklist

A capable supplier should be able to identify the material unambiguously as CAS 71597-85-8 and provide a product specification that matches the quotation. I also recommend asking whether the supplier can provide a representative sample, batch-specific CoA, SDS, packaging information, and technical support for storage and transport. These documents allow the buyer’s quality and technical teams to review the material before purchase approval.

• Confirm CAS number, molecular formula, molecular weight, and product naming.
• Request the current specification and a representative or batch-specific CoA.
• Check assay method, identity testing, impurity controls, water content, and appearance criteria.
• Review packaging, labeling, lot traceability, and storage instructions.
• Clarify MOQ, sample policy, standard pack sizes, lead time, and shipment terms.
• Ask how complaints, deviations, replacement requests, and specification changes are managed.

How Maison Chemical Can Support Sourcing

At Maison Chemical, I approach organic boronic acid sourcing as a technical and procurement task rather than a simple catalog transaction. Our support can include product identification, specification review, quotation preparation, packaging discussion, document coordination, and communication about available supply options. Where the application requires tighter controls, I recommend sharing the intended use and required acceptance criteria before the order is finalized.

For repeat projects, we can also discuss forecast quantities, preferred packaging, sampling needs, and delivery planning. Any quality, availability, or lead-time statement should be confirmed against the specific order and lot, which protects both the buyer and the supplier from assumptions. This approach is particularly useful when 4-hydroxyphenylboronic acid is being evaluated for scale-up or multi-batch use.

Key Takeaways and Next Steps

4-Hydroxyphenylboronic acid CAS 71597-85-8 is a useful para-substituted aryl boronic acid building block with a molecular weight of approximately 137.93 g/mol. Its main sourcing considerations are verified identity, assay, impurity profile, moisture control, packaging, and suitability for the intended reaction. Solubility and reaction performance should be confirmed under the buyer’s actual solvent, base, catalyst, and substrate conditions.

The best next step is to prepare a concise purchasing specification and send it to Maison Chemical with the required quantity, target application, desired assay, documentation needs, and delivery location. We can then help compare available options, clarify MOQ and lead time, and provide the documentation needed for technical and procurement review. This structured process gives buyers a more reliable basis for selecting 4-hydroxyphenylboronic acid for laboratory, development, or manufacturing use.

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