4-Hydroxycyclohexanone Ethylene Acetal CAS 22428-87-1: Properties, Uses, and Sourcing Guide

4-Hydroxycyclohexanone ethylene acetal, identified by CAS 22428-87-1, is a protected cyclohexanone derivative used primarily as an organic synthesis intermediate. Its ethylene acetal group masks the ketone functionality, while the hydroxyl group provides a separate site for further chemical transformation. For procurement, I recommend confirming the molecular identity, assay, water content, appearance, packaging, and intended synthetic route before placing an order. Maison Chemical supports buyers with specification review, sample coordination, documentation, and project-based supply for pharmaceutical and specialty chemical applications.

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Who This Guide Is For

This guide is intended for pharmaceutical intermediate buyers, medicinal chemistry teams, process development laboratories, custom synthesis companies, and distributors evaluating CAS 22428-87-1. It is also useful for purchasing teams that need to compare several suppliers without relying only on a catalogue name. Because the material may be used at different stages of a synthetic route, the most suitable specification depends on the downstream reaction and process scale.

I recommend using this guide as a starting point rather than as a substitute for a current technical data sheet or certificate of analysis. Chemical names can be written in more than one acceptable form, and similar protected ketone intermediates may appear in supplier databases under different naming conventions. A structure check and CAS confirmation should therefore be part of every sourcing process.

Basic Concept and Chemical Identity

What the compound is

4-Hydroxycyclohexanone ethylene acetal is a cyclohexane-based compound containing an ethylene acetal-protected ketone and a secondary alcohol. The acetal is commonly introduced to reduce the reactivity of a ketone during subsequent transformations, allowing other functional groups to be modified with improved route control. The hydroxyl group can be used for reactions such as activation, substitution, oxidation, or coupling, depending on the overall synthesis.

The compound is commonly associated with the systematic description 1,4-dioxaspiro[4.5]decan-8-ol, although buyers should verify the exact structural representation with the supplier. Its molecular formula is generally represented as C₈H₁₄O₃, with a calculated molecular weight of approximately 158.20 g/mol. These identity data are useful for database searching, analytical method development, and checking stoichiometric calculations.

Properties and Functional Value

Protected ketone behavior

The ethylene acetal is the key functional feature of this intermediate. In a synthetic sequence, it can help protect the ketone from selected basic, nucleophilic, or reducing conditions, although compatibility must always be assessed for the specific reaction. Acetal deprotection is commonly associated with acidic conditions, but the required reagent, temperature, solvent, and reaction time depend on the route and should be established experimentally.

The hydroxyl group creates a second point of synthetic flexibility. A process chemist may convert it into a leaving-group derivative, introduce a substituted side chain, or use it as a handle for downstream functionalization. I do not recommend assuming that every batch will perform identically without reviewing the actual assay, impurity profile, water content, and analytical data.

Physical and handling considerations

Commercial appearance, melting behavior, and storage recommendations should be confirmed from the current product specification because these details may vary with purity, residual solvent, and batch form. Buyers should request information on appearance, assay method, related substances, residual solvents, and water content before approving a batch. The material should be handled according to its current safety data sheet, with appropriate laboratory controls and personal protective equipment.

Packaging should protect the intermediate from contamination, moisture exposure, and unsuitable temperature conditions during storage and transport. If the material is intended for a sensitive multi-step synthesis, I suggest requesting a representative sample and comparing it with the buyer’s internal reference standard. A documented retest or shelf-life policy should also be discussed for inventory that will remain in storage.

Types, Material Options, and Specification Levels

Suppliers may offer this compound in different package sizes and quality levels, but the product name alone does not define the complete specification. A research-use batch may be appropriate for route screening, while a process-development batch may require tighter controls on impurities, residual solvents, water, and lot-to-lot consistency. For regulated pharmaceutical development, the buyer may also need traceability documents and a more formal change-control process.

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Recommended specification review

• Identity: CAS number, chemical structure, molecular formula, and confirmation by an appropriate analytical technique.
• Assay: The analytical method and reporting basis should be stated clearly rather than relying only on a rounded purity claim.
• Impurity profile: Identify related organic impurities and any route-specific residual materials that could affect the next step.
• Residual solvents and water: These values may influence reaction concentration, catalyst performance, and crystallization behavior.
• Physical form: Confirm whether the material is supplied as a solid, liquid, or other defined form under the stated storage conditions.
• Documentation: Request the SDS, specification sheet, certificate of analysis, and available batch traceability information.

Matching the Intermediate to Applications

The most common value of CAS 22428-87-1 is its role as a building block in medicinal chemistry and pharmaceutical intermediate synthesis. Its protected carbonyl and hydroxyl functionality can support route designs where selective reactions are required at different stages. It may also be considered for specialty organic synthesis, reference work, and process research when the chemical structure fits the target route.

For early discovery work, buyers may prioritize availability, small sample quantities, and rapid analytical confirmation. During process development, the priorities usually shift toward reproducibility, impurity control, scalable packaging, and reliable replenishment. Before moving to larger quantities, I recommend confirming that the acetal remains intact through the planned reaction sequence and that the hydroxyl group behaves as expected under process conditions.

A Practical Selection Framework

Step 1: Confirm the structure

Start with the CAS number, structure drawing, molecular formula, and molecular weight. If your internal database uses a synonym such as 1,4-dioxaspiro[4.5]decan-8-ol, ask the supplier to confirm that it refers to the same stereochemical and constitutional structure required by your project. This step helps prevent substitution with a non-equivalent hydroxycyclohexanone derivative.

Step 2: Define the required quality level

Specify whether you need material for screening, route development, pilot work, or commercial manufacturing support. Share any critical limits for assay, water, residual solvents, and specific impurities. A supplier can provide a more useful quotation when the intended application and acceptance criteria are known.

Step 3: Review supply conditions

Ask for available package sizes, minimum order quantity, sample policy, lead-time estimate, shipping conditions, and document availability. Lead time and MOQ are project-dependent, so I recommend requesting a current quotation instead of relying on a general catalogue assumption. For repeat purchasing, discuss batch reservation, production planning, and notification procedures for specification changes.

Pricing, MOQ, and Lead-Time Considerations

The cost of this intermediate can depend on purity requirements, batch size, analytical workload, raw material availability, packaging, and delivery destination. A small research quantity may carry a higher unit cost than a larger development batch because fixed handling and testing activities are distributed across less material. The lowest quoted price is therefore not always the lowest total procurement cost.

Lead time should be evaluated together with documentation and quality review. A supplier that can provide a clear specification, representative analytical data, and responsive technical communication may reduce delays during incoming inspection. For projects with a fixed development schedule, I suggest qualifying an alternative supply option before the material becomes a critical-path intermediate.

Supplier Evaluation Checklist

1. Can the supplier confirm CAS 22428-87-1 and the required chemical structure?
2. Is the assay method stated on the specification or certificate of analysis?
3. Can the supplier provide batch-specific analytical documentation?
4. Are packaging, storage, transport, and retest recommendations clearly defined?
5. Can the supplier support samples, repeat orders, and changing project volumes?
6. Is technical communication available when the buyer needs to assess route compatibility?

How Maison Chemical Supports Buyers

At Maison Chemical, I approach CAS 22428-87-1 as a project-related pharmaceutical intermediate rather than a name-only catalogue item. We can review your target specification, intended application, quantity requirement, packaging preference, and delivery destination before preparing a supply proposal. Where appropriate, we can also coordinate sample evaluation and provide the available technical and commercial documents for your internal review.

Our support is designed for buyers who need clear communication between laboratory, quality, purchasing, and logistics teams. We do not recommend approving a material solely on a generic product description; instead, we encourage confirmation of the current batch information and acceptance criteria. This approach helps make the sourcing decision more transparent and reduces avoidable qualification issues.

Key Takeaways and Next Steps

• 4-Hydroxycyclohexanone ethylene acetal is a protected cyclohexanone intermediate with a reactive hydroxyl group.
• CAS 22428-87-1, formula C₈H₁₄O₃, and approximate molecular weight 158.20 g/mol are useful identity checkpoints.
• The best specification depends on whether the material is used for screening, process development, or a more controlled pharmaceutical supply program.
• Buyers should review assay, impurities, residual solvents, water, physical form, packaging, documentation, MOQ, and lead time before ordering.

In conclusion, CAS 22428-87-1 can be a practical building block when a synthesis requires a protected ketone together with a hydroxyl-based functionalization site. The correct purchasing decision depends on verified identity, route compatibility, documented quality, and dependable supply support. To discuss your required quantity, specification, sample need, or delivery schedule, contact Maison Chemical with your target parameters and we will prepare a suitable B2B sourcing response.

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