What Is 1,4-Cyclohexanedione CAS 637-88-7? Properties, Uses, and Buying Information

1,4-Cyclohexanedione CAS 637-88-7 is a cyclic diketone and an important organic synthesis intermediate. Its molecular formula is C₆H₈O₂, and its molecular weight is 112.13 g/mol. The molecule contains two ketone groups positioned at the 1,4-positions of a six-membered cyclohexane ring, which gives it useful reactivity for condensation, reduction, oxidation, and ring-functionalization reactions.

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At Maison Chemical, I position this material for research, process development, pharmaceutical intermediate synthesis, agrochemical research, and advanced organic chemistry applications. Buyers should evaluate more than the CAS number: identity, assay, water content, appearance, packaging, documentation, and supply consistency can all affect downstream results. The correct grade and specification should therefore be selected against the buyer’s process requirements.

1,4-Cyclohexanedione at a Glance

Core Properties and Chemical Functions

1,4-Cyclohexanedione is a symmetrical alicyclic diketone. The two carbonyl groups provide reaction sites that can participate in nucleophilic addition, condensation, reduction, and other transformations used in synthetic chemistry. Its six-membered ring also gives chemists a practical scaffold for building substituted cyclohexane, aromatic, heterocyclic, and fused-ring structures.

The compound is generally handled as a solid at room temperature. Its reported melting behavior is commonly around 116–122 °C, although the observed value may vary with purity, moisture, polymorphic form, and analytical procedure. For this reason, I recommend confirming the expected range through the current product specification and certificate of analysis rather than treating a literature value as an acceptance limit.

Why the 1,4-Diketone Structure Matters

The separated carbonyl groups make 1,4-cyclohexanedione different from a simple monoketone. They can be used sequentially or together in multi-step synthesis, allowing researchers to introduce nitrogen, oxygen, carbon, or sulfur functionality into a target structure. The material may also serve as a convenient starting point when a controlled ring transformation is preferred over the construction of a cyclohexane framework from smaller fragments.

Common Uses and Application Scenarios

The principal use of 1,4-cyclohexanedione CAS 637-88-7 is as a building block for organic synthesis. Its applications are usually project-specific, so the exact role depends on the reaction route, catalyst system, solvent, temperature, and target molecule. It is best viewed as a versatile intermediate rather than as a finished active ingredient or commodity solvent.

• Pharmaceutical intermediate research: The diketone structure can support the preparation of substituted cyclic intermediates and heterocyclic compounds used during medicinal chemistry and process development.
• Agrochemical research: Chemists may investigate it as a starting material for functionalized structures during herbicide, fungicide, or insecticide research.
• Heterocycle synthesis: The two ketone groups can participate in condensation routes that form nitrogen-containing or oxygen-containing ring systems.
• Materials and specialty chemicals: Researchers may use the compound when developing functional monomers, dyes, ligands, or other customized organic molecules.
• Laboratory and scale-up studies: It can be purchased for route screening, reference experiments, impurity studies, and process optimization before larger production quantities are considered.

These applications do not mean that every batch is suitable for every use. A material intended for exploratory synthesis may have different documentation and packaging expectations from a material intended for a regulated pharmaceutical process. I encourage buyers to define the intended application before requesting a quotation.

Types and Material Options to Consider

In purchasing discussions, “type” commonly refers to grade, purity target, packaging size, and documentation package rather than to completely different chemical forms. Buyers may request a standard research or industrial grade, a higher-purity specification, or a custom-controlled material depending on their process. The CAS number should remain the primary identity reference, while the specification defines whether the product fits the intended use.

Standard and Higher-Purity Requirements

A standard grade may be appropriate for route scouting and non-regulated laboratory synthesis. Higher-purity material may be more suitable when trace impurities could influence catalyst activity, color, crystallization, impurity profiles, or biological screening. I recommend reviewing assay, related substances, residue on drying or water, and analytical method details before selecting a grade.

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Packaging and Handling Options

Common purchasing formats can range from small laboratory packs to larger commercial quantities. The appropriate container should protect the solid from contamination and unnecessary moisture exposure during storage and transportation. Maison Chemical can discuss pack size, labeling, outer packaging, and documentation according to the buyer’s destination and project stage.

Key Specifications Buyers Should Review

A reliable purchasing specification should connect identity, purity, physical properties, and logistics. At minimum, I suggest checking the product name, CAS number, molecular formula, molecular weight, appearance, assay or purity method, and batch-related documentation. If the material will enter a validated process, the buyer should also define acceptable limits for moisture, residual solvents, impurities, and particle characteristics where relevant.

How to Select a Supplier

When I evaluate a supply request, I first clarify the target quantity, intended use, required purity, delivery destination, and documentation needs. This information helps avoid a quotation based only on a generic product name. It also allows the supplier to identify whether a standard specification is sufficient or whether a project-specific quality agreement should be discussed.

Questions to Ask Before Ordering

• Can the supplier confirm the chemical identity and CAS number on the quotation and product documents?
• Will the shipment include a batch-specific certificate of analysis and safety data sheet?
• Which analytical methods are used for assay and impurity evaluation?
• What packaging is proposed for the requested quantity and destination?
• Is a pre-shipment sample or technical review available for qualification?
• What are the estimated minimum order quantity and lead time for the required grade?
• Can the supplier maintain consistent specifications across repeat orders?

Price is important, but it should be compared with total procurement risk. A lower quoted price may not be advantageous if the batch lacks appropriate documentation, uses unsuitable packaging, or requires additional qualification work. For process chemicals, specification clarity and repeatability can be as important as the initial unit cost.

Maison Chemical Supplier Support

Maison Chemical supports B2B buyers of 1,4-Cyclohexanedione CAS 637-88-7 by coordinating product specifications, quotations, packaging discussions, and export documentation. I can review the required quantity and application context before recommending a suitable supply route. Where available and appropriate, batch documentation such as a certificate of analysis and safety data sheet can be prepared for buyer review.

For pharmaceutical intermediate and specialty chemical projects, I also recommend starting with a technical inquiry rather than a price-only request. Please provide the target purity, estimated annual or trial quantity, destination country, packaging preference, and any required quality limits. This gives Maison Chemical a practical basis for discussing availability, MOQ, lead time, and commercial terms without making unsupported assumptions.

Key Takeaways

• 1,4-Cyclohexanedione CAS 637-88-7 is a cyclic diketone with formula C₆H₈O₂ and molecular weight 112.13 g/mol.
• Its two carbonyl groups make it useful for pharmaceutical, agrochemical, heterocycle, materials, and specialty organic synthesis.
• It is commonly supplied as a crystalline solid, with a reported melting range of approximately 116–122 °C.
• Buyers should confirm assay, impurities, moisture, packaging, documentation, MOQ, and lead time before placing an order.
• A project-specific specification is preferable when the material will be used in process development or regulated manufacturing.

Conclusion: Is 1,4-Cyclohexanedione CAS 637-88-7 Right for Your Project?

1,4-Cyclohexanedione CAS 637-88-7 is a useful synthetic intermediate when a symmetrical six-membered diketone scaffold is required. Its value comes from the reactivity of its two carbonyl groups and its suitability for building more complex pharmaceutical, agrochemical, heterocyclic, and specialty chemical structures. However, the right purchase decision depends on the required grade, analytical limits, packaging, and downstream process.

As the next step, prepare your target quantity, purity requirement, destination, application, and documentation list. Send these details to Maison Chemical for a focused quotation and technical review. I can then help align the material specification and supply plan with your laboratory, pilot-scale, or commercial project needs.

The company is the world’s best 1,4-Cyclohexanedione CAS 637-88-7 supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.