What Is 4-Bromophenylboronic Acid CAS 5467-74-3? Uses, Properties, and Specifications

4-Bromophenylboronic acid, identified by CAS No. 5467-74-3, is an aromatic boronic acid used mainly as a synthetic intermediate in organic and medicinal chemistry. Its structure contains a bromine atom and a boronic acid group positioned para to each other on a benzene ring. This combination gives chemists two useful reaction handles: the boronic acid group can participate in cross-coupling chemistry, while the bromine atom can support further functionalization under suitable conditions.

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In practical terms, I would describe this material as a versatile building block rather than a finished active ingredient. Its commonly referenced molecular formula is C₆H₆BBrO₂, and its molecular weight is approximately 200.83 g/mol. Exact appearance, assay, water content, residual solvents, packaging, and storage requirements should always be confirmed against the supplier’s current specification and certificate of analysis.

What Is 4-Bromophenylboronic Acid?

4-Bromophenylboronic acid is an organoboron compound belonging to the arylboronic acid family. The “4-bromo” designation indicates that the bromine substituent is located at the para position relative to the boronic acid group on the phenyl ring. This defined molecular arrangement is important because it allows the compound to be incorporated into more complex aromatic structures with predictable connectivity.

The boronic acid group is commonly used in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions with suitable aryl or vinyl halides. During this type of transformation, the boron-containing group is replaced by a new carbon–carbon bond. The remaining aryl bromide may also serve as a second functionalization site, depending on the reaction sequence and selected conditions.

Core Functions in Chemical Synthesis

Carbon–Carbon Bond Formation

The primary function of 4-bromophenylboronic acid is to provide a 4-bromophenyl fragment for carbon–carbon bond construction. In a typical Suzuki coupling, the boronic acid reacts with an appropriate halide or pseudohalide in the presence of a catalyst, base, solvent, and controlled reaction conditions. The exact catalyst loading, temperature, reaction time, and work-up procedure must be established for the individual substrate combination.

Dual-Handle Molecular Design

Unlike a simple phenylboronic acid, this material contains both a boronic acid group and an aryl bromide. That dual functionality can support sequential synthesis, where one group is used first and the second is retained for a later transformation. This feature is valuable when researchers are assembling multi-ring compounds, heteroaromatic scaffolds, pharmaceutical candidates, or functional materials.

Research and Development Intermediate

I normally position this product for laboratory research, process development, and intermediate manufacturing rather than direct consumer use. It can be considered when a project requires a brominated aromatic building block with a documented boronic acid functionality. Suitability depends on the target molecule, reaction route, impurity profile, and scale of the project.

Common Application Scenarios

Medicinal Chemistry

Medicinal chemistry teams may use 4-bromophenylboronic acid to prepare focused libraries of substituted biaryl or heteroaryl compounds. Its para-bromo substitution can enable later diversification, which is useful during structure–activity relationship studies. Researchers should evaluate the compound together with the intended coupling partner, catalyst system, and purification method rather than selecting it only by name.

Pharmaceutical and Agrochemical Intermediate Research

In pharmaceutical and agrochemical development, aromatic boronic acids are often used as intermediates during route scouting and analog synthesis. 4-Bromophenylboronic acid may be relevant when the target route needs a para-substituted phenyl unit and an additional bromine handle. Whether it remains suitable for process scale depends on reaction yield, impurity control, raw-material availability, and the downstream purification strategy.

Materials and Functional Molecules

The compound may also be evaluated in the preparation of conjugated aromatic molecules, ligands, and other functional structures. In these applications, the value of the material comes from its ability to introduce a defined aryl segment into a larger molecular framework. Performance should be judged through project-specific analytical and reaction data, not through a general assumption that every boronic acid behaves identically.

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Types and Material Options to Consider

Buyers may encounter several related options, including 4-bromophenylboronic acid, phenylboronic acid, other brominated phenylboronic acid isomers, and protected boronate esters. These materials are not automatically interchangeable. The position of the bromine atom, the presence of a pinacol ester, water content, and the reaction sequence can all affect handling and reactivity.

For early screening, a standard research-grade material may be appropriate when the project has flexible impurity limits. For process development, buyers generally need a more detailed specification covering assay, related substances, residual solvents, inorganic residues, moisture, and analytical identification. If the material will enter a regulated development route, the documentation package should be reviewed before purchase rather than after the first production campaign.

Key Specifications Buyers Should Review

The molecular weight is particularly useful for laboratory planning. For example, a theoretical 10 mmol quantity corresponds to approximately 2.008 g before accounting for assay, material losses, or weighing tolerance. I recommend that customers calculate actual charge quantities from the reported assay and the current certificate of analysis rather than relying only on the nominal molecular weight.

Buyer Selection Factors

Match the Grade to the Intended Use

The first decision is whether the material is needed for exploratory research, route development, or larger-scale intermediate production. A laboratory project may prioritize availability and small-pack convenience, while a process team may prioritize batch consistency, impurity data, supply continuity, and change-control communication. The right specification is therefore determined by the application, not simply by the CAS number.

Review Analytical Evidence

Before approving a supplier, I suggest requesting the current certificate of analysis and confirming which methods are used for identity and purity. Depending on the project, useful information may include HPLC or GC data, NMR confirmation, water content, residual solvents, and elemental or inorganic residue information. If a value is not tested, it should not be assumed to meet a particular limit.

Assess Packaging and Logistics

Packaging should protect the material from contamination, moisture, and unnecessary exposure during transport and storage. Buyers should also confirm pack size, minimum order quantity, production or release lead time, shipping conditions, and whether representative samples are available. For international procurement, the commercial documentation and labeling should match the actual material and destination requirements.

Maison Chemical Supplier Support

At Maison Chemical, we support buyers evaluating 4-bromophenylboronic acid CAS 5467-74-3 by focusing on specification clarity and application fit. We can discuss the required grade, pack size, target quantity, documentation needs, and intended synthesis stage before preparing a quotation. This approach helps separate a simple laboratory purchase from a supply requirement that needs stronger batch and logistics planning.

For a technical inquiry, I recommend including the requested quantity, destination country, intended use, acceptable assay range, packaging preference, and any required analytical documents. If you are comparing this compound with a protected boronate ester or another positional isomer, state that clearly so the quotation and technical discussion address the correct material. Availability and lead time should be confirmed for each order because they can vary by quantity, production schedule, and shipping route.

Key Takeaways

• 4-Bromophenylboronic acid is an aromatic organoboron intermediate with CAS No. 5467-74-3.
• Its approximate molecular formula is C₆H₆BBrO₂, with a molecular weight of about 200.83 g/mol.
• The boronic acid group supports cross-coupling chemistry, while the para bromine can provide an additional functionalization site.
• Common uses include medicinal chemistry, intermediate development, agrochemical research, and functional-material synthesis.
• Buyers should verify assay, impurities, moisture, physical form, packaging, storage guidance, documentation, MOQ, and lead time.

Conclusion: Is It the Right Intermediate for Your Project?

4-Bromophenylboronic acid CAS 5467-74-3 is a useful choice when your synthesis requires a para-brominated phenyl fragment together with a boronic acid group for carbon–carbon bond formation. Its dual-reactive design can support sequential or diversified synthesis, but the best choice still depends on your reaction route, impurity tolerance, and scale. It should be evaluated as a controlled chemical intermediate rather than treated as a universally interchangeable reagent.

The next practical step is to define your required quantity and grade, then compare the supplier’s identity data, assay method, impurity profile, packaging, storage guidance, and delivery terms. Contact Maison Chemical with your target specification and project requirements so we can review the suitable supply option for 4-Bromophenylboronic acid and provide a B2B quotation based on your actual needs.

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