What Is 1,4-Dioxaspiro[4,5]dec-7-en-8-boronic Acid Pinacol Ester CAS 680596-79-6?

1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester, identified by CAS 680596-79-6, is a boronic ester building block used primarily in synthetic organic chemistry and pharmaceutical intermediate development. Its key functional feature is an alkenyl boronate group, which can participate in palladium-catalyzed cross-coupling chemistry such as Suzuki–Miyaura reactions. The spirocyclic dioxolane structure also provides a protected ketone equivalent that may be carried through several synthetic steps and revealed later, depending on the reaction conditions.

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In practical purchasing terms, I recommend treating this material as a specialized research and process-development intermediate rather than as a general-purpose commodity chemical. Buyers should confirm the identity, assay, water content, appearance, storage conditions, and analytical documentation for the specific batch. At Maison Chemical, we support project-based sourcing for customers who need product information, quotation evaluation, and supply coordination for this compound.

Product Identity and Chemical Role

What the name describes

The name contains several structural clues. “1,4-Dioxaspiro[4,5]dec-7-en” describes a spirocyclic framework containing two oxygen atoms in a cyclic acetal ring and an alkene within the fused numbering system. “8-Boronic acid pinacol ester” indicates that the boronic acid functionality is present in a more practically handled pinacol ester form, commonly written as a Bpin group.

This combination gives the molecule two useful synthetic elements in one intermediate: a carbon–boron bond for cross-coupling and a cyclic acetal that can serve as a protected carbonyl functionality. The exact reaction performance still depends on the substrate, catalyst, base, solvent, temperature, and work-up procedure. I therefore recommend using supplier documentation and process-specific experiments rather than assuming that one standard condition will apply to every route.

Basic identification data

Formula and molecular-weight information should be checked against the current product specification and certificate of analysis before use in regulated documentation. Minor differences between databases can arise from naming conventions, rounding, or catalog-record errors. For purchasing and process control, the CAS number should be used together with an analytical identity check, not as the only release criterion.

Core Functions in Synthetic Chemistry

Cross-coupling building block

The boronic ester group is the most prominent reaction handle in this molecule. Under suitable Suzuki–Miyaura coupling conditions, the alkenyl carbon attached to boron can be connected with an appropriate aryl, heteroaryl, or vinyl halide or related electrophile. The resulting product retains the spirocyclic acetal framework, which can be useful for constructing more complex intermediates.

Reaction compatibility is not automatic. Catalyst selection, ligand choice, base strength, moisture, and the stability of the coupling partner can influence conversion and selectivity. When I help buyers assess this product, I suggest reviewing the intended coupling partner and route conditions before deciding whether a small evaluation quantity or a larger process quantity is appropriate.

Protected carbonyl equivalent

The cyclic acetal portion can function as a protected carbonyl equivalent in a multistep synthesis. Protection may allow other transformations to proceed without exposing a reactive ketone during earlier stages. Later deprotection may be possible under appropriately selected acidic or aqueous conditions, although the practical outcome depends on the complete molecular structure and reaction environment.

This dual-function design can reduce the need to introduce and protect separate functional groups at different points in a route. It does not eliminate route-development work, however, because acetal stability and boronate stability may not respond identically to the same conditions. A process chemist should evaluate the sequence as a whole, including isolation and purification requirements.

Application Scenarios

Pharmaceutical intermediate research

Researchers may use CAS 680596-79-6 when developing pharmaceutical or advanced intermediate routes that require a spirocyclic scaffold and a cross-coupling handle. The compound can be particularly relevant when medicinal chemistry teams are exploring substitution around an alkenyl position. Its role is as a synthetic input, not as an active pharmaceutical ingredient or finished dosage material.

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Medicinal chemistry and library synthesis

In discovery programs, a boronic ester can support the preparation of analogues from a common intermediate. A research team may couple the boronate with different electrophiles to examine changes in aromatic or heteroaromatic substituents. Actual library productivity will depend on reaction scope, purification capacity, and the stability of each resulting analogue.

Process and route development

Process chemists may evaluate this intermediate during route scouting, scale-up, or manufacturing preparation. At this stage, the most important questions often concern batch consistency, impurity profile, handling, packaging, and repeat availability. A supplier that can provide clear documentation and communicate realistic lead times may reduce sourcing risk, even when the initial order volume is modest.

Types, Material Options, and Key Specifications

This product is generally purchased as a research or synthesis-grade solid, but the commercially available form, color, packaging, and assay can vary by supplier and batch. Some buyers require a standard catalog batch, while others need a specification aligned with an internal intermediate control strategy. I recommend distinguishing between “catalog availability” and “manufacturing readiness,” because they are not always equivalent.

For boronic esters, moisture exposure and prolonged unsuitable storage may affect material quality, so the supplier’s handling instructions should be followed. I do not recommend inferring stability from the chemical name alone. Buyers should request a current certificate of analysis and, where required, supporting chromatographic or spectroscopic data before approving the material for a defined project.

How Buyers Should Select a Supplier

Technical documentation

A suitable supplier should be able to identify the product consistently by CAS 680596-79-6 and provide a batch-specific certificate of analysis. Depending on the application, useful documentation may include HPLC or GC data, NMR information, water content, residual solvent information, and a safety data sheet. The exact document package should match the buyer’s internal quality and regulatory requirements.

Supply and commercial factors

Price should be evaluated together with pack size, minimum order quantity, lead time, packaging, freight requirements, and the cost of qualification. A low unit price may not be advantageous if the material is unavailable for follow-up batches or if documentation is incomplete. For development projects, I suggest comparing at least one evaluation quantity with the expected demand for the next synthesis phase.

Customization and project support

For customers with defined specifications, a supplier may need to review target assay, impurity expectations, packaging, delivery location, and forecast volume before confirming feasibility. Custom requests should be treated as a technical and commercial assessment rather than an automatic promise of availability. Maison Chemical can coordinate these questions with buyers and provide a practical quotation pathway based on the project’s requirements.

Summary Insight

• CAS 680596-79-6 is an alkenyl boronic acid pinacol ester containing a spirocyclic acetal framework.
• Its principal synthetic value is the combination of a cross-coupling handle and a protected carbonyl equivalent.
• The commonly listed molecular weight is 264.13 g/mol, while batch-specific identity and purity must be confirmed from supplier documentation.
• Key purchasing checks include assay method, water content, residual solvents, storage, packaging, MOQ, lead time, and repeat-batch capability.

Conclusion: Is This the Right Intermediate for Your Project?

1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester CAS 680596-79-6 is a specialized synthetic building block for routes that benefit from both an alkenyl boronate and a protected cyclic carbonyl structure. It may be suitable for pharmaceutical intermediate research, medicinal chemistry, and process-development work, provided that the planned reaction sequence is compatible with both functional groups. The correct choice should be based on route requirements and batch documentation rather than the product name alone.

As the next step, prepare your target quantity, required assay, delivery destination, documentation needs, and intended application before requesting a quotation. Maison Chemical can review these details, confirm available supply information, and help determine whether a standard batch or a project-specific specification is more appropriate. Contact our chemicals team for a product inquiry and a sourcing discussion tailored to your development schedule.

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