2-Bromophenylboronic Acid CAS 244205-40-1: A Buyer’s Guide to Properties, Uses, and Supply

I use this guide to help research teams, procurement managers, and pharmaceutical or agrochemical manufacturers evaluate 2-Bromophenylboronic acid CAS 244205-40-1 before purchase. This compound is an ortho-bromo aryl boronic acid used mainly as a multifunctional building block in cross-coupling and other synthetic routes. Its practical value comes from combining a boronic acid group, which can participate in Suzuki–Miyaura coupling, with an aryl bromide that may support further functionalization under suitable reaction conditions.

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For buying decisions, I recommend confirming the identity, assay, water content, appearance, analytical documentation, packaging, and supply schedule rather than selecting only by name or price. The molecular formula commonly associated with this CAS number is C₆H₆BBrO₂, with a molecular weight of approximately 200.83 g/mol. Exact specifications should always be verified against the supplier’s current specification sheet and certificate of analysis.

Who This Guide Is For

This guide is intended for chemists planning a new synthetic route, purchasing teams sourcing research or production quantities, and companies comparing multiple suppliers of organic boronic acids. It is also useful for organizations that need to assess whether a standard catalog grade is sufficient or whether they require tighter controls, custom packaging, or a larger-scale supply plan. I focus on practical purchasing and technical evaluation rather than making unsupported claims about reaction performance.

What 2-Bromophenylboronic Acid Is

2-Bromophenylboronic acid is an aromatic boronic acid containing both a boronic acid functionality and a bromine substituent on the phenyl ring. The “2-bromo” designation indicates that the bromine is positioned ortho to the boronic acid group. This substitution pattern can influence steric behavior, solubility, reaction handling, and the way the intermediate performs in a specific synthetic sequence.

The compound is commonly supplied as a solid, often described as a white to off-white crystalline or powder-like material, although appearance can vary with manufacturing, drying, and storage conditions. A typical commercial specification may define an assay such as 97% or higher, but I do not treat that value as universal; buyers should request the actual specification and batch CoA for the material being quoted.

Key Properties and Specification Points

When I evaluate this material for a customer, I separate identity data from batch-release data. CAS 244205-40-1, molecular formula, and molecular weight help establish the expected chemical identity, while assay, residual solvents, water, impurities, and analytical profiles determine whether a particular batch is suitable for the intended process.

Some technical databases and suppliers may report different physical descriptions or melting behavior because test methods, purity, polymorphic form, and moisture exposure can affect observed values. For this reason, I recommend using a supplier-issued specification rather than relying on an isolated online data point. If a defined melting range is important for process control, ask for the test method and batch result before approving the material.

Uses and Application Matching

Suzuki–Miyaura Coupling

The most recognizable use of 2-Bromophenylboronic acid is as an aryl boronic acid partner in Suzuki–Miyaura coupling. Under an appropriate palladium catalyst, base, solvent, and reaction design, the boronic acid group can couple with a suitable aryl or vinyl halide to form a carbon–carbon bond. Actual conversion and selectivity depend on the reaction substrate, catalyst system, water content, temperature, base, and work-up procedure, so I avoid treating the compound as a guaranteed high-yield solution for every route.

Intermediate and Building-Block Chemistry

The bromine substituent gives the molecule additional synthetic flexibility because it can remain available for later transformation or be used as part of a sequential route. Chemists may therefore consider this material when they need an aromatic intermediate with two differentiated reactive handles. Suitability should be established through route-specific evaluation, especially when steric effects around the ortho position may affect coupling, purification, or downstream selectivity.

Research and Process Development

In medicinal chemistry and process research, the compound may be purchased for analogue preparation, route scouting, impurity studies, and intermediate development. For early-stage work, a standard research grade may be adequate if identity and assay are documented. For process development, I recommend adding controls for water, residual solvents, trace metals, particle handling, and lot-to-lot consistency where those factors can affect reproducibility.

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Material Options Buyers Should Compare

“Grade” does not always mean the same thing across suppliers, so I encourage buyers to compare the underlying documents. Common options include research-grade material, higher-assay material for process development, and custom-produced batches with defined impurity or packaging requirements. A supplier may also offer different pack sizes, such as gram-level quantities for laboratory screening or larger packages for route development, but available sizes and minimum order quantities must be confirmed during quotation.

Buyers should also distinguish between a standard product and a custom supply program. A standard product usually supports faster quotation and simpler purchasing, while a custom program may provide tighter specifications, dedicated production planning, or tailored packaging. Customization can require additional development time and may change the commercial MOQ, so I recommend discussing the intended annual or project volume at the beginning.

A Practical Selection Framework

1. Confirm Chemical Identity

Start by matching the product name, CAS number, molecular formula, and molecular weight. I also recommend requesting an identity test such as NMR, IR, or another suitable method listed on the supplier’s CoA. This step helps prevent confusion with positional isomers, hydrated materials, or similarly named bromophenylboronic acids.

2. Define the Required Quality Level

Next, determine which attributes are critical to your reaction and downstream purification. Assay is important, but it may not be the only relevant parameter; water, residual solvents, inorganic residues, palladium or other trace metals, and specific organic impurities can also matter. If your process has an established impurity limit, provide that limit to the supplier instead of requesting only a general “high-purity” grade.

3. Review Handling and Packaging

Because boronic acids can be sensitive to moisture and storage conditions, I recommend keeping the material in a tightly closed, appropriately labeled container in a cool, dry environment, following the current SDS and supplier instructions. Packaging should protect the solid from contamination and unnecessary humidity exposure during transport and storage. For larger orders, ask whether the proposed inner and outer packaging is suitable for your handling system and local transport requirements.

4. Check Supply and Documentation

Before placing an order, request the current CoA, SDS, specification sheet, batch or lot information, packaging details, and estimated lead time. If the compound will enter a regulated or quality-controlled workflow, clarify whether the supplier can support additional documentation or audit questions. I advise buyers to approve a representative sample or first lot before committing to a broader supply plan when the material is route-critical.

Pricing, MOQ, and Lead-Time Considerations

The price of 2-Bromophenylboronic acid can vary with assay, pack size, production route, raw material costs, testing requirements, packaging, and order volume. I do not recommend comparing quotations using price per gram alone because a lower unit price may exclude additional testing, special packaging, or longer delivery time. A complete comparison should include the delivered specification, documentation package, Incoterms, freight, and any minimum order condition.

MOQ and lead time are normally quotation-based rather than fixed universal values. Small laboratory quantities may be available from stock, while larger or customized batches may require production scheduling and pre-shipment testing. When contacting Maison Chemical, I suggest providing the required quantity, target assay, destination, packaging preference, and expected repeat demand so we can prepare a more relevant commercial response.

Supplier Evaluation Checklist

• Can the supplier confirm CAS 244205-40-1 and provide a current CoA?
• Does the specification clearly state assay, identity, water, and relevant impurities?
• Are packaging, storage, labeling, and transport conditions documented?
• Can the supplier support samples, repeat lots, and production-scale inquiries?
• Are MOQ, lead time, payment terms, and shipping terms stated clearly?
• Can the supplier discuss custom specifications without making unsupported performance promises?

Key Takeaways

• 2-Bromophenylboronic acid CAS 244205-40-1 is a multifunctional aromatic building block used particularly in cross-coupling and intermediate synthesis.
• The commonly associated molecular formula is C₆H₆BBrO₂, and the approximate molecular weight is 200.83 g/mol.
• Assay alone is not enough; identity, water, residual solvents, impurities, packaging, and documentation should be reviewed together.
• MOQ, price, and lead time depend on quantity, grade, testing, packaging, and supply planning.

Conclusion: How to Buy with Greater Confidence

In my view, the best way to source 2-Bromophenylboronic acid CAS 244205-40-1 is to match the material specification to the actual synthetic route, then verify the supplier’s documentation and supply capability. The compound is a useful aryl boronic acid building block, but its performance must be judged in the context of the catalyst system, reaction substrate, impurity tolerance, and downstream process. A documented specification and representative sample provide a more reliable basis for approval than a catalog description alone.

Maison Chemical can support buyers evaluating standard or project-specific requirements for this organic boronic acid. To request a quotation, please share your target quantity, required assay or impurity limits, packaging needs, destination, and desired delivery schedule. I will use that information to help you compare a practical supply option for research, process development, or ongoing manufacturing needs.

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