4-Hydroxyphenylboronic Acid CAS 71597-85-8 Buyer’s Guide to Specifications, Applications, and Supply

4-Hydroxyphenylboronic acid, CAS 71597-85-8, is an aryl boronic acid used mainly as a synthetic building block in pharmaceutical, agrochemical, fine chemical, and advanced material research. Its molecular formula is C₆H₇BO₃, and its molecular weight is approximately 137.93 g/mol. For B2B purchasing, the most important decisions are not limited to chemical identity: buyers should also confirm assay, impurity profile, packaging, documentation, lead time, and the supplier’s ability to support repeat orders.

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At Maison Chemical, I recommend evaluating this material against the specific reaction, process scale, and quality system in which it will be used. The correct specification depends on whether the product is intended for laboratory development, route screening, process development, or commercial manufacturing. This guide explains how I would structure that evaluation before requesting a quotation or placing a purchase order.

Who This Buyer’s Guide Is For

This guide is intended for procurement teams, process chemists, R&D laboratories, formulation developers, and distributors sourcing 4-Hydroxyphenylboronic acid for professional use. It is especially relevant when a buyer needs more than a catalog description and must compare multiple suppliers on quality, documentation, logistics, and continuity of supply. It can also help technical and purchasing departments create a shared specification before commercial discussions begin.

The material may be purchased in small quantities for method development or in larger quantities for repeated synthesis. These use cases create different requirements for batch consistency, packaging, analytical data, and delivery planning. A supplier that is suitable for an exploratory project may not automatically be suitable for a regulated or scale-up program, so the purchasing objective should be defined first.

Basic Chemical Context

4-Hydroxyphenylboronic acid contains both a boronic acid functional group and a para-hydroxy-substituted aromatic ring. The boronic acid group is commonly used in carbon–carbon bond-forming chemistry, while the phenolic group provides an additional functional handle for downstream transformation or molecular design. These two reactive features make the compound useful as an intermediate rather than as a finished functional product.

One of its best-known roles is as an aryl partner in palladium-catalyzed Suzuki–Miyaura coupling reactions. In a typical synthetic sequence, the boronic acid reacts with an appropriate aryl or vinyl halide to form a new carbon–carbon bond. Actual performance depends on the reaction system, catalyst, base, solvent, temperature, substrate structure, and the handling history of the raw material, so buyers should avoid treating the chemical name alone as a guarantee of reaction outcome.

Specifications Buyers Should Confirm

Identity and Core Quality Data

The first specification checkpoint is identity confirmation for CAS 71597-85-8, including the chemical name, molecular formula, molecular weight, and an appropriate analytical identification method. Buyers commonly request a certificate of analysis showing assay or purity, appearance, batch or lot number, manufacturing date, and retest or review information where applicable. The exact acceptance criteria should be agreed before shipment rather than assumed from a general product listing.

For many synthesis applications, buyers also review related substances, water content, residual solvents, and inorganic residues. These parameters can influence reaction reproducibility, isolation behavior, and downstream purification. If the material will enter a sensitive process, I recommend asking for the supplier’s available analytical methods and discussing whether additional testing can be arranged for project-specific requirements.

Physical Form, Packaging, and Handling

Appearance and physical form should be recorded in the purchasing specification, while color and powder characteristics should be evaluated against the agreed batch standard. Packaging must protect the material from moisture, contamination, and repeated exposure during warehouse or laboratory use. The appropriate package size depends on consumption rate, shelf-life planning, and whether the customer operates under a controlled dispensing process.

Storage instructions should be taken from the supplier’s current technical documentation and product label. Buyers should also review the relevant safety data sheet before handling, especially when establishing internal procedures for personal protective equipment, ventilation, waste management, and transport. If a project requires a defined storage temperature or special packaging, that requirement should be stated during quotation rather than after order confirmation.

Application Matching

Pharmaceutical and Fine Chemical Synthesis

In medicinal chemistry and pharmaceutical intermediate development, 4-Hydroxyphenylboronic acid can serve as a building block for constructing biaryl or heteroaryl-linked molecules. The phenolic group may also be retained, protected, or further functionalized depending on the route design. For these applications, a buyer should focus on lot-to-lot consistency, trace impurity control, and documentation that supports internal material qualification.

Agrochemical and Specialty Intermediate Development

Specialty chemical developers may use this compound during the preparation of substituted aromatic intermediates. The preferred specification can vary according to the number of reaction steps that follow, the sensitivity of the target molecule, and the purification strategy. In an early-stage project, a standard commercial grade may be sufficient, while later process work may require tighter controls for specific impurities or residual solvents.

Research and Advanced Materials

The compound may also be considered in research involving functional aromatic molecules, sensors, and boron-containing molecular systems. In these projects, the required quality profile may include attention to trace metals, moisture, color, or functional-group integrity. Because these requirements are application-dependent, buyers should provide a short technical description of the intended use when requesting a quotation.

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A Practical Selection Framework

Step 1: Define the Intended Use

Start by documenting whether the material is for discovery research, process development, pilot production, or routine manufacturing. Record the expected annual demand, preferred delivery schedule, and whether the product will be used in a regulated quality environment. This information helps the supplier recommend a realistic grade, packaging format, and supply arrangement.

Step 2: Set the Critical Quality Attributes

Separate mandatory requirements from preferred requirements. Mandatory items may include identity, minimum assay, defined impurity limits, documentation, or a specific packaging configuration, while preferred items may include shorter lead time or additional analytical testing. This approach prevents buyers from paying for unnecessary specifications while still protecting the performance of the intended process.

Step 3: Review Commercial and Supply Conditions

Price should be compared together with MOQ, lead time, freight terms, payment conditions, packaging, and testing charges. A low unit price may not be advantageous if the minimum order is excessive or if replenishment is uncertain. For planning purposes, buyers should request both the current availability and the estimated lead time for a repeat order, because these may differ.

Step 4: Approve a Representative Lot

Before committing to a larger program, request a sample or representative batch when the project requires formal qualification. Review the certificate of analysis against the agreed specification and, where appropriate, compare the material in the customer’s own reaction system. A documented approval process makes future purchasing decisions more consistent and provides a clear basis for discussing any batch-related concern.

Common Purchasing Mistakes

One common mistake is selecting a supplier solely by catalog purity without checking the test method or impurity information. “High purity” can have different meanings depending on the analytical technique and reporting basis, so the buyer should request the actual specification and batch data. Another mistake is failing to confirm whether the quoted material is in stock, made to order, or subject to production scheduling.

Buyers should also avoid assuming that every supplier provides the same documentation package. A certificate of analysis, safety data sheet, packing list, and shipping documents may be standard, while additional declarations or custom testing may require advance arrangement. Finally, do not postpone packaging and storage discussions until after the purchase order, because these details can affect product condition, handling, and logistics.

Pricing, MOQ, and Lead-Time Considerations

The commercial cost of 4-Hydroxyphenylboronic acid is influenced by quantity, grade, analytical requirements, packaging, production status, and shipping destination. I recommend requesting at least two quantity breaks so that the buyer can compare development-scale purchasing with a planned repeat-order model. Exact pricing should be confirmed through a current quotation because market conditions and production schedules can change.

MOQ is not only a commercial number; it also affects inventory exposure and material aging. For early-stage work, a smaller package may reduce unnecessary stock, while a qualified production program may benefit from a planned bulk supply arrangement. Lead time should be discussed in calendar days or weeks, with separate confirmation for in-stock material, sample preparation, and new production.

How Maison Chemical Can Support B2B Buyers

Maison Chemical supplies 4-Hydroxyphenylboronic acid CAS 71597-85-8 for professional chemical sourcing and can support buyers during product specification, documentation review, quotation, and shipment coordination. I can help organize the information needed for a practical evaluation, including intended application, target quantity, required purity, packaging preference, destination, and documentation requirements. This technical-commercial approach is useful when several departments must approve the same raw material.

For repeat programs, I recommend establishing an agreed specification and communication process before the first commercial order. The supply discussion can then cover batch documentation, packaging, forecast visibility, sample or approval requirements, and the handling of any change in production or logistics conditions. Where a customer has a special requirement, it should be reviewed in advance so that feasibility is confirmed rather than assumed.

Key Takeaways and Next Steps

4-Hydroxyphenylboronic acid CAS 71597-85-8 is a versatile aromatic boronic acid used primarily as a synthetic intermediate, especially in coupling-based molecular construction. Its formula is C₆H₇BO₃ and its molecular weight is approximately 137.93 g/mol, but identity data alone are not enough for a sound B2B purchase. Buyers should confirm assay, impurity controls, analytical documentation, packaging, storage guidance, MOQ, lead time, and repeat-order capability.

The most practical next step is to send Maison Chemical your target quantity, intended application, required specification, destination country, and documentation needs. We can then review the appropriate supply option and provide current commercial information for evaluation. By aligning technical requirements with procurement conditions before ordering, you can reduce avoidable sourcing risk and create a clearer path from laboratory development to repeat supply.

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