What Is 3,4,5-Trifluorophenylboronic Acid CAS 143418-49-9 Used For?

3,4,5-Trifluorophenylboronic acid, identified by CAS 143418-49-9, is a fluorinated aryl boronic acid used mainly as a synthetic building block. I supply it to research, pharmaceutical, agrochemical, and advanced-material development teams that need an aromatic boronic acid for carbon–carbon bond formation, especially Suzuki–Miyaura coupling. Its structure combines a phenyl ring, three fluorine substituents, and a boronic acid functional group, giving chemists a practical route to introduce a highly fluorinated aryl fragment into a larger molecule.

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In commercial use, this compound is generally purchased as an intermediate rather than as a final active ingredient. Its value depends on the customer’s reaction design, required purity, scale, analytical documentation, packaging, and delivery schedule. At Maison Chemical, I focus on helping buyers evaluate the material against their specific synthesis and procurement requirements instead of treating one specification as suitable for every project.

Key Takeaways

• 3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 is primarily used as a fluorinated aryl building block.
• Its best-known application is palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides.
• It can support medicinal chemistry, agrochemical research, process development, and selected materials-synthesis programs.
• The molecular formula is commonly represented as C₆H₄BF₃O₂, with a calculated molecular weight of approximately 175.91 g/mol.
• Buyers should confirm assay, water content, residual solvents, packaging, batch documentation, and scale before placing an order.

What This Compound Is

Structure and Chemical Role

3,4,5-Trifluorophenylboronic acid contains a boronic acid group attached to a phenyl ring substituted with fluorine atoms at the 3, 4, and 5 positions. The boronic acid group is the reactive handle that enables coupling chemistry, while the fluorinated ring becomes part of the final molecular structure. The compound has three fluorine atoms per molecule, which is a useful structural feature when a project requires a specific electron-deficient aromatic fragment.

Like other aryl boronic acids, this material should be handled according to the supplier’s safety documentation and the user’s laboratory or production procedures. Boronic acids can be affected by moisture, oxidation, storage conditions, and reaction media, so I recommend confirming the product specification and recommended storage conditions before opening a commercial package. The exact behavior in a synthesis will also depend on the coupling partner, catalyst system, base, solvent, temperature, and work-up method.

Primary Uses of 3,4,5-Trifluorophenylboronic Acid

1. Suzuki–Miyaura Coupling

The most direct use is as a coupling partner in Suzuki–Miyaura reactions. In this reaction family, an aryl or heteroaryl boronic acid can react with an appropriate aryl, heteroaryl, or vinyl halide under catalytic conditions to form a new carbon–carbon bond. This allows chemists to attach the 3,4,5-trifluorophenyl group to another molecular fragment during the preparation of a target compound.

The exact reaction performance cannot be guaranteed from the product name alone. Chemists normally screen catalyst, ligand, base, solvent, temperature, stoichiometry, and reaction time because fluorinated substrates may respond differently from non-fluorinated analogues. For this reason, I position the product as a synthesis-ready building block, not as a universal solution for every coupling protocol.

2. Pharmaceutical and Medicinal Chemistry Research

Medicinal chemistry teams use fluorinated aromatic building blocks when exploring structure–activity relationships, molecular size, lipophilicity, metabolic stability, or electronic effects. The 3,4,5-trifluorophenyl group can be introduced into candidate molecules through a planned coupling step, allowing researchers to compare it with other substituted phenyl groups. Such comparisons are project-specific, and the final biological performance must be established through the customer’s own analytical and biological testing.

This compound is therefore useful during hit expansion, lead optimization, and analog preparation when the target structure includes a trifluorinated aromatic ring. It may also support the preparation of reference compounds, intermediates, and small libraries. I recommend that buyers provide the intended reaction type and approximate scale so the supplied grade and documentation can be matched to the development stage.

3. Agrochemical and Crop-Protection Research

Fluorinated aromatic fragments are also used in the design and optimization of agrochemical research compounds. A boronic acid intermediate can help researchers build new carbon–carbon bonds while varying the rest of the molecular structure. This is particularly relevant when a development program needs a controlled series of analogues rather than a single isolated compound.

However, the presence of fluorine does not by itself prove biological activity, regulatory suitability, environmental performance, or commercial potential. Those properties depend on the complete molecule and must be evaluated through appropriate testing. I therefore recommend using 3,4,5-trifluorophenylboronic acid as a synthetic input for discovery and process work, not as evidence of a finished crop-protection product.

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4. Specialty Materials and Organic Synthesis

Some research groups may use this intermediate in the preparation of functional aromatic molecules, ligands, probes, or other specialty organic compounds. The relevant use is determined by whether the final target benefits from a 3,4,5-trifluorophenyl unit and whether a boronic-acid coupling route is compatible with the synthesis. Potential materials applications should be described conservatively because the compound is an intermediate, not a finished performance material.

Material Options and Specification Considerations

For B2B purchasing, the important distinction is usually not a different chemical identity but the level of documentation, purity control, packaging, and supply support required for the project. A discovery laboratory may prioritize a practical research quantity and a certificate of analysis, while a process-development team may require tighter impurity control, defined packaging, and repeat-batch consistency. I can discuss these requirements before quotation so the order is aligned with actual use.

The approximate molecular weight is 175.91 g/mol, which buyers can use for preliminary stoichiometric calculations. This value should not replace the supplier’s technical documentation or the customer’s own analytical verification. Depending on the project, I may also need to review requested quantity, destination, intended application, documentation format, and whether the material is for laboratory research or a later manufacturing stage.

How Buyers Should Select a Supplier

Review Technical Documentation

I recommend requesting a current certificate of analysis, specification sheet, safety data sheet, and available analytical data before approving a supplier. The documents should identify the product clearly and explain the tested parameters, methods, and acceptance criteria. If a buyer requires a particular test method or format, that requirement should be stated before the purchase order rather than assumed after delivery.

Match Grade to Project Stage

For early discovery, the priority may be reliable identity, appropriate purity, manageable packaging, and fast communication. For process development, buyers generally need greater attention to impurity trends, batch comparability, supply continuity, and scale-up logistics. A material that is adequate for a small reaction screen may require additional review before being introduced into a validated or regulated manufacturing process.

Confirm Supply and Logistics

Lead time, minimum order quantity, export documentation, packaging, and shipping conditions can affect the real purchasing cost. I advise buyers to request a quotation based on the exact quantity and destination because commercial terms vary by order size and delivery location. Maison Chemical can review these details and provide a practical supply proposal without making unsupported claims about universal availability or fixed delivery times.

Supplier Support from Maison Chemical

At Maison Chemical, I support B2B customers sourcing 3,4,5-trifluorophenylboronic acid CAS 143418-49-9 for research, development, and international supply programs. My role is to clarify the requested specification, confirm the intended application, coordinate available documentation, and discuss packaging or quantity requirements. Where a project has special analytical or logistics needs, I encourage the buyer to communicate them at the inquiry stage.

I also recognize that purchasing a chemical intermediate is not only a price decision. Buyers need confidence that the material identity is clear, the documentation is usable, the packaging matches the handling plan, and future orders can be evaluated consistently. For that reason, I aim to provide a transparent quotation and a technically focused response rather than an absolute performance promise.

Conclusion: What Is It Used For?

3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 is mainly used as a fluorinated aryl building block in organic synthesis, with Suzuki–Miyaura coupling being its most important application context. It can help pharmaceutical, agrochemical, medicinal chemistry, and specialty-synthesis teams introduce a 3,4,5-trifluorophenyl fragment into more complex molecules. Its suitability depends on the complete reaction design, required purity, analytical controls, and project stage.

As a next step, send Maison Chemical your target quantity, intended application, required purity, destination, and documentation needs. I can then help assess the appropriate supply format and prepare a B2B quotation for your project. This approach gives you a clearer basis for evaluating both technical fit and procurement practicality.

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