A Guide to 4-Isopropylbenzeneboronic Acid CAS 16152-51-5 Specifications and Applications

4-Isopropylbenzeneboronic acid, also known as 4-isopropylphenylboronic acid, is an aromatic boronic acid used primarily as a boron-containing building block in organic synthesis and medicinal chemistry research. Its CAS number is 16152-51-5, and its molecular formula is commonly represented as C₉H₁₃BO₂, with a calculated molecular weight of approximately 164.01 g/mol. I recommend evaluating this material through its identity, assay, water content, appearance, and application-specific performance rather than relying on the chemical name alone.

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At Maison Chemical, I support B2B buyers by helping them match 4-Isopropylbenzeneboronic acid with the right specification, documentation package, packaging format, and supply plan. Because physical appearance, assay, residual solvents, and storage recommendations can vary by manufacturing route and batch, the current product specification and certificate of analysis should always be confirmed before purchase.

Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical researchers, contract development and manufacturing organizations, university laboratories, process chemists, procurement teams, and distributors sourcing organic boronic acids. It is also useful for buyers comparing laboratory-scale material with larger-volume synthesis-grade supply. The goal is to provide a practical framework for evaluating CAS 16152-51-5 before placing an inquiry or purchase order.

The compound may be relevant to organizations developing Suzuki–Miyaura coupling reactions, screening substituted aromatic intermediates, or preparing more complex molecules for research and development. It is not a finished drug ingredient or an application-ready formulation. Instead, it is a reactive intermediate whose suitability depends on the reaction design, purification strategy, and quality requirements of the end user.

Basic Chemical Concept and Core Specifications

4-Isopropylbenzeneboronic acid contains an aryl boronic acid group and an isopropyl substituent positioned at the para position of the benzene ring. The boronic acid group is the principal reactive site and can participate in carbon–carbon bond-forming chemistry under suitable reaction conditions. The isopropyl group modifies the steric and electronic characteristics of the aromatic ring, which can be useful when researchers are building substituted biaryl or related structures.

What the Specification Should Usually Address

A useful specification should identify the compound clearly and define measurable quality attributes. Depending on the intended use, a buyer may request assay by an appropriate analytical method, related substances, water content, residual solvents, and elemental or inorganic impurity information. An assay target such as 98% or higher should only be accepted when it is supported by the supplier’s current specification and batch testing, not treated as an automatic property of every commercial lot.

Appearance is also relevant, but visual description alone is not sufficient for material qualification. Buyers should compare the supplier’s identification data with their own analytical method, such as NMR, HPLC, GC where appropriate, or another validated technique. I recommend confirming whether the quoted material is supplied as a free boronic acid and whether any stabilizer, solvent, hydrate, or special packaging condition applies.

Applications and Application Matching

Suzuki–Miyaura and Related Cross-Coupling Research

The most direct application area is the use of an aryl boronic acid as a coupling partner in carbon–carbon bond formation. In a typical Suzuki–Miyaura development program, the boronic acid is combined with a suitable aryl or vinyl halide, base, catalyst system, and solvent selected by the chemist. Actual conversion and selectivity depend on the reaction substrates and conditions, so I do not recommend treating CAS 16152-51-5 as universally compatible with every coupling protocol.

Pharmaceutical and Agrochemical Intermediate Development

The para-isopropyl substitution pattern can provide a defined aromatic fragment for medicinal chemistry libraries and intermediate research. It may be used when a development team wants to introduce a substituted biaryl motif or explore the effect of a hydrophobic aromatic group in a target structure. Whether it is suitable for a regulated process depends on impurity control, process reproducibility, documentation, and the customer’s own qualification requirements.

Custom Synthesis and Discovery Chemistry

Research organizations may use this compound as a starting material for preparing analogues, screening compounds, and route-development intermediates. In these settings, small pack sizes and rapid technical communication can be more important than long-term volume pricing. For scale-up, the buyer should move from a research-grade discussion to a documented supply plan covering batch consistency, packaging, change notification, and delivery expectations.

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Available Material Options and Selection Framework

The appropriate material option depends on the purpose of the purchase. A small research package may be sufficient for feasibility testing, while a process-development project may require a larger quantity with tighter impurity controls and a defined resupply plan. Buyers should also distinguish between a product that is suitable for exploratory synthesis and one that has been qualified for a validated or controlled manufacturing process.

1. Define the application: state whether the material is for screening, route scouting, process development, or commercial manufacturing support.
2. Set the quality requirement: identify assay, impurity, water, residual solvent, and appearance expectations before requesting a quotation.
3. Confirm analytical support: request a current COA and ask which methods are used for identity and purity assessment.
4. Review packaging: confirm container type, net weight, labeling, and whether moisture-protective handling is recommended.
5. Plan supply continuity: discuss sample availability, MOQ, lead time, repeat-batch consistency, and production capacity.

For an initial technical evaluation, a buyer may request a 1–5 g sample when that quantity is sufficient for the planned experiments. Larger projects should be quoted against a defined batch size and delivery schedule rather than an approximate annual estimate. This approach allows the supplier to assess feasibility accurately and reduces the risk of a mismatch between laboratory expectations and commercial supply.

Handling, Storage, and Documentation Considerations

As with other laboratory and synthesis chemicals, 4-Isopropylbenzeneboronic acid should be handled by trained personnel using the supplier’s current safety data sheet and the customer’s internal chemical safety procedures. The product should be protected from conditions identified in the SDS, including unsuitable heat, moisture, ignition sources, or incompatible chemicals. Storage temperature and packaging requirements should be confirmed from the specific supplier documentation rather than assumed from the product name.

Before use, I recommend checking the container label, lot number, appearance, and certificate of analysis against the purchase order. If the material will be used in sensitive synthesis, the receiving team may also compare the supplied NMR or chromatographic data with an internal reference method. Any unusual discoloration, damaged packaging, or discrepancy in documentation should be placed on hold and reported to the supplier before processing.

Pricing, MOQ, Lead Time, and Supplier Evaluation

Pricing for CAS 16152-51-5 can vary according to quantity, assay requirement, analytical package, packaging, production route, and shipping destination. A low unit price may not represent the best total sourcing value if the material requires additional testing or if the supplier cannot support repeat orders. I suggest requesting a tiered quotation for sample, pilot, and production quantities so that the commercial comparison reflects the complete project need.

MOQ and lead time should be confirmed in writing because they may differ between in-stock research material and made-to-order production. Buyers should ask whether the quoted lead time begins after payment, technical approval, or purchase-order confirmation. They should also confirm shelf-life information, retest policy, transportation conditions, export documents, and the process for reporting quality concerns.

Supplier Checklist for B2B Buyers

• Does the quotation clearly identify CAS 16152-51-5 and the required product name?
• Is a batch-specific COA available for review?
• Can the supplier provide an SDS and suitable transport documentation?
• Are assay, impurity, water, and residual solvent limits clearly defined?
• Can the supplier support the requested package size and delivery destination?
• Is there a practical plan for repeat supply and specification change communication?

Key Takeaways

4-Isopropylbenzeneboronic acid CAS 16152-51-5 is an aryl boronic acid building block with the formula C₉H₁₃BO₂ and an approximate molecular weight of 164.01 g/mol. Its principal value is its use as a defined aromatic boron reagent in organic synthesis, especially in research involving cross-coupling and substituted aromatic intermediates. The correct grade is determined by the buyer’s reaction, impurity tolerance, documentation needs, packaging requirement, and expected volume.

Maison Chemical can help B2B customers review the required specification, confirm available pack sizes, provide current technical documents, and discuss sample or bulk supply options. For the next step, send the intended application, target quantity, destination, desired assay, and documentation requirements. I can then help develop a quotation and sourcing plan based on the actual project rather than a generic product description.

Conclusion

When selecting 4-Isopropylbenzeneboronic acid CAS 16152-51-5, buyers should focus on verified identity, batch-specific quality data, application fit, safe handling information, and dependable supply support. The chemical name and CAS number establish the starting point, but they do not replace a current COA, SDS, and clearly agreed commercial specification. A disciplined qualification process is especially important when moving from discovery-scale experiments to process development or repeat procurement.

Maison Chemical is ready to support your evaluation of this organic boronic acid with product information, packaging discussion, documentation review, and B2B quotation assistance. Contact our team with your required quantity and technical criteria so we can recommend the most suitable supply route for your project.

Contact us to discuss your requirements of 4-Isopropylbenzeneboronic acid CAS 16152-51-5. Our experienced sales team can help you identify the options that best suit your needs.