4-Tolylboronic Acid CAS 5720-05-8: Applications, Specifications, and Sourcing Guide

4-Tolylboronic acid, also called 4-methylphenylboronic acid or p-tolylboronic acid, is an arylboronic acid used mainly as a coupling building block in organic synthesis. Its CAS number is 5720-05-8, its molecular formula is C₇H₉BO₂, and its molecular weight is approximately 135.96 g/mol. Buyers typically evaluate it for Suzuki–Miyaura coupling work, where the para-methylphenyl group is transferred to a suitable coupling partner. This guide explains its uses, identity checks, purchasing considerations, and the information to confirm with a supplier before ordering.

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Key Takeaways

• 4-Tolylboronic acid is an organoboron reagent used to introduce a para-methylphenyl group in synthesis, especially in palladium-catalyzed cross-coupling.
• Confirm identity, assay or purity basis, appearance, packaging, and batch documentation against the specification required for your process.
• Price, minimum order quantity, and lead time depend on the requested grade, quantity, packaging, and current supply status; request a project-specific quotation.
• For weighing calculations, 1 mmol corresponds to approximately 135.96 mg of the pure compound, before accounting for assay or handling losses.

Who This Guide Is For

This guide is intended for procurement teams, process chemists, research laboratories, and manufacturers assessing 4-Tolylboronic acid as a synthesis raw material. It is useful whether you are planning an initial laboratory evaluation or qualifying a material for a larger project. The information helps define what to ask for, but it does not replace a project-specific risk assessment or review of the supplier’s documentation. If your process has strict impurity, regulatory, or change-control requirements, share those requirements before requesting a quotation.

Basic Concept and Chemical Context

4-Tolylboronic acid contains a phenyl ring bearing a methyl substituent in the para position and a boronic acid group attached to the ring. In a typical Suzuki–Miyaura reaction, an organoboron reagent couples with an appropriate organic halide or related electrophile in the presence of a catalyst and suitable reaction conditions. The reaction can form a carbon–carbon bond, making the reagent useful in the preparation of substituted aromatic compounds. The actual outcome depends on the substrate, catalyst system, solvent, base, and process conditions.

The compound’s formula is C₇H₉BO₂, and its molecular weight is approximately 135.96 g/mol. For a theoretical charge of 10 mmol of pure material, the calculated mass is about 1.360 g; the actual weighed amount may need adjustment based on the batch assay stated in the product documentation. These calculations are starting points for material planning, not a substitute for confirming the certificate of analysis and your laboratory’s weighing procedure. Use the supplier’s current product and safety documentation to guide handling and storage.

Applications and Material Fit

Suzuki–Miyaura Coupling

The principal use of 4-Tolylboronic acid is as a coupling partner for installing a para-methylphenyl group. It may be selected when a target molecule or intermediate requires that specific aromatic substitution pattern. Chemists generally assess its suitability through reaction development with the intended coupling partner rather than assuming that one set of conditions will work across substrates. For scale-up, confirm that reaction performance, impurity control, and work-up are acceptable under the planned process.

Intermediate and Building-Block Synthesis

The reagent may be considered in research and development, medicinal chemistry, and fine-chemical synthesis where aryl–aryl or related carbon–carbon bond formation is part of the route. Its value is tied to the para-tolyl group it contributes, not to a universal application or guaranteed yield. If the target requires a different substitution position, another arylboronic acid may be more appropriate. Confirm the desired regioisomer and structure before purchase, especially when several tolylboronic acid isomers appear in a sourcing list.

Specifications and Identity Checks

CAS 5720-05-8 identifies 4-Tolylboronic acid, but a CAS number alone is not a complete purchasing specification. Before placing an order, align the required grade and acceptance criteria with the supplier’s offered specification. At minimum, review the product name, CAS number, molecular formula, molecular weight, assay or purity method, appearance description, and batch-specific documentation where available. If a particular analytical method or impurity limit is essential, state it explicitly in the inquiry.

Do not treat a generic catalogue value as a guarantee for a specific shipment. Batch results, documentation, and available grades should be confirmed for the material being quoted. Where the compound will be used in a sensitive reaction or regulated workflow, agree on the required analytical evidence and acceptance criteria before purchase. This reduces the chance of receiving material that is chemically identified correctly but does not meet your internal process requirements.

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Selection Framework for Buyers

Match the Material to the Intended Use

Start by defining whether the material is for screening, route development, pilot work, or routine production. These uses may require different quantities, documentation, packaging, and impurity controls. Provide the supplier with the intended grade and any application-specific requirements rather than requesting only “4-Tolylboronic acid.” If your team has an approved specification, attach it or list the key limits in the inquiry.

Assess Quality and Documentation Needs

Ask how the quoted assay is determined and whether a batch-specific certificate of analysis is supplied. Confirm that the stated test method and result format can be reviewed by your quality or technical team. If you require additional testing, special packaging, or a particular document set, check feasibility and any effect on cost or lead time before issuing a purchase order. Avoid assuming that a standard offer includes customer-specific testing or regulatory documentation.

Compare Commercial Terms

Pricing for specialty intermediates can vary with order quantity, grade, packaging, availability, and shipping destination. Minimum order quantity and lead time are also supplier- and order-specific, so they should be confirmed in a written quotation rather than inferred from a catalogue listing. For planning, request the price breaks available for your expected consumption and ask whether the quoted delivery estimate begins after order confirmation or another defined milestone. Include the destination country and preferred shipment terms so the offer can address the actual requirement.

Pricing, MOQ, and Lead-Time Considerations

There is no single dependable price, minimum order quantity, or delivery time that applies to every buyer and shipment. These commercial details may depend on current stock, requested quantity, grade, packaging configuration, export requirements, and destination. When comparing offers, evaluate the total procurement fit rather than unit price alone, including documentation, delivery terms, and whether the quoted material meets your specification. Ask the supplier to confirm quotation validity and any conditions that could affect fulfillment.

For an efficient quotation, provide the required quantity, target delivery date, destination, desired grade or assay, packaging preference, and documentation requirements. If you are still evaluating the material, indicate whether a smaller evaluation quantity is acceptable and ask what options are currently available. This gives the supplier a clearer basis for checking feasibility without implying that a particular pack size or lead time is guaranteed. Confirm all final commercial and technical terms in the order documents.

Supplier Evaluation Checklist

• Does the supplier confirm the correct compound, CAS number, and para-substituted isomer?
• Can the supplier provide the specification and batch documentation required for your use?
• Are assay basis, test method, packaging, and storage guidance clearly stated?
• Are price, minimum order quantity, delivery estimate, and shipping terms confirmed in writing?
• Can the supplier review special requirements before the order is placed?

Maison Chemical supports B2B inquiries for 4-Tolylboronic acid CAS 5720-05-8, including requests for product details, quotations, and export supply coordination. We recommend that buyers share their quantity, destination, required documentation, and specification needs so we can assess the request accurately. Availability, packaging, lead time, and documentation should be confirmed for each order. This approach helps align the commercial offer with the buyer’s technical and logistics requirements.

Conclusion and Next Steps

4-Tolylboronic acid CAS 5720-05-8 is a para-methyl-substituted arylboronic acid used primarily as a building block in cross-coupling synthesis. Its core identity is defined by the formula C₇H₉BO₂ and molecular weight of approximately 135.96 g/mol, while suitability for a particular process depends on the target reaction and the material specification. Before sourcing, verify the isomer, assay basis, documentation, packaging, and commercial terms for the specific batch and order. To request a quotation from Maison Chemical, send your required quantity, destination, target delivery schedule, and technical or documentation requirements for review.

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