What Is 4-Hydroxycyclohexanone Ethylene Acetal CAS 22428-87-1? Properties, Uses, and Buying Information

4-Hydroxycyclohexanone ethylene acetal, CAS 22428-87-1, is a protected cyclohexanone derivative used primarily as a specialty organic building block and pharmaceutical intermediate. Its ethylene acetal group masks the ketone functionality, while the hydroxyl group remains available for further chemical transformation. I recommend treating it as a synthesis intermediate rather than as a finished active pharmaceutical ingredient, and buyers should confirm the exact grade, assay, impurity profile, and documentation before placing an order.

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At Maison Chemical, I support B2B customers evaluating this material for research, process development, and manufacturing supply. Common purchasing questions involve identity, functional-group behavior, handling, batch consistency, packaging, and export documentation. The most reliable buying decision combines the CAS number with a current specification sheet, safety data sheet, certificate of analysis, and a clear description of the intended application.

Summary of Key Information

• Product identity: 4-Hydroxycyclohexanone ethylene acetal
• CAS Registry Number: 22428-87-1
• Common structural description: a cyclohexanol derivative containing an ethylene ketal, also described as a protected 4-hydroxycyclohexanone derivative
• Common role: organic synthesis intermediate and pharmaceutical research building block
• Approximate molecular formula: C₈H₁₄O₃
• Approximate molecular weight: 158.20 g/mol
• Key purchasing documents: specification sheet, SDS, COA, and batch-specific analytical data where required

What Is 4-Hydroxycyclohexanone Ethylene Acetal?

The compound is a cyclic acetal, more specifically an ethylene ketal, derived from 4-hydroxycyclohexanone. In this structure, the original ketone carbonyl is converted into a five-membered 1,3-dioxolane ring through reaction with ethylene glycol. This protection can help chemists carry out selected reactions at another position while reducing direct participation of the ketone group.

The molecule also contains a secondary alcohol at the 4-position of the cyclohexane ring. As a result, it offers two useful features for synthetic planning: a protected carbonyl equivalent and a free hydroxyl group that can participate in derivatization. The acetal is generally considered acid-sensitive, so reaction conditions, storage conditions, and downstream deprotection requirements should be assessed during process development.

Identity and Nomenclature Considerations

Commercial catalogs may use related names such as 4-hydroxycyclohexanone ethylene ketal or 4-(1,3-dioxolan-2-yl)cyclohexanol. These names describe the same general structural framework, but nomenclature alone should not replace identity confirmation. I advise buyers to compare the CAS number, molecular formula, molecular weight, structural representation, and analytical profile supplied for the specific batch.

Core Chemical Functions and Properties

The main chemical value of CAS 22428-87-1 comes from its functional-group arrangement. The ethylene acetal protects the ketone-derived carbonyl carbon, while the alcohol provides a handle for esterification, etherification, oxidation, or other transformations selected by the process chemist. The exact reaction suitability depends on the reagents, solvent, temperature, catalyst, and purification method.

Physical appearance, color, assay, water content, residual solvents, and impurity levels can vary according to manufacturing route and commercial grade. I do not recommend assuming a universal melting point, boiling point, appearance, or purity value without reviewing the supplier’s current batch documentation. For regulated or scale-up work, the customer’s internal analytical method should be compared with the supplier’s test method before approval.

Potential Applications

Pharmaceutical and Medicinal Chemistry

4-Hydroxycyclohexanone ethylene acetal may be used as an intermediate in the preparation of more complex small molecules. Its protected ketone and available alcohol can support sequential synthesis strategies in which chemists need to control the order of functional-group transformations. Whether it is appropriate for a specific pharmaceutical route depends on the target structure, impurity controls, reaction yield, and regulatory requirements.

Specialty Organic Synthesis

The compound can also be evaluated in academic, industrial, and contract research programs involving substituted cyclohexane frameworks. The hydroxyl group may be converted into other derivatives, while the acetal can later be retained or removed according to the planned route. These are potential synthetic uses, not a guarantee of performance in every reaction system.

Process Development and Route Screening

During route design, buyers may require small quantities for reaction screening before moving to larger campaign volumes. A consistent material profile is important because water, residual solvent, regioisomeric impurities, or unprotected carbonyl-containing impurities may influence reaction behavior. For this reason, I recommend requesting representative analytical data and discussing scale requirements at the beginning of the sourcing process.

Material Options and Specification Expectations

Suppliers may offer this material in research, development, or production-oriented quantities. The most important distinction is usually not a simple “type” classification, but the agreed specification and intended use. A development batch may be acceptable for route exploration, while a manufacturing program may require tighter controls for assay, water, residual solvents, related substances, packaging, and lot-to-lot consistency.

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Typical specification discussions may include assay by an appropriate chromatographic method, identification by spectroscopy or chromatography, water content, appearance, and selected organic impurities. If the material will enter a regulated supply chain, buyers should define documentation expectations before quotation, including COA format, SDS language, labeling, traceability, and change-notification procedures. No specification should be considered confirmed until it appears in the approved commercial or technical documents.

How to Select a Suitable Supplier

Confirm Identity Before Comparing Price

I recommend starting with CAS 22428-87-1, the structural name, and the intended synthesis route. Ask whether the quoted material is the protected acetal rather than 4-hydroxycyclohexanone or another related cyclohexane intermediate. A structure review is especially important when a purchasing system uses abbreviated names or when several suppliers use different synonyms.

Review Quality and Batch Information

Request a current COA or representative specification showing the analytical parameters relevant to your application. For initial evaluation, customers commonly review assay, water, appearance, and chromatographic purity, although the final list should be based on the process requirements. If a supplier cannot clearly explain its testing scope, batch traceability, or retest policy, the buyer should treat that as a sourcing risk.

Evaluate Packaging, Logistics, and Commercial Terms

Packaging should protect the material from contamination, moisture exposure, and handling damage during storage and transportation. Confirm the available pack size, MOQ, production lead time, shipping terms, dangerous-goods classification if applicable, and export documents before issuing a purchase order. Lead time is not a fixed property of the chemical; it depends on stock status, batch scheduling, quantity, destination, and document requirements.

Handling and Storage Considerations

Because acetal stability can be affected by acidic conditions, the material should be stored and handled according to the supplier’s SDS and technical guidance. Containers should remain properly closed, and exposure to unnecessary heat, moisture, contamination, and incompatible chemicals should be minimized. Laboratory and plant personnel should use the controls, personal protective equipment, and ventilation requirements specified by their risk assessment.

Specific storage temperature, shelf life, and re-evaluation period should come from the supplier’s documentation rather than from a generic assumption. Buyers should also confirm whether the material requires a particular inert-gas practice or special transport packaging for their route. Maison Chemical can discuss these requirements during technical and commercial evaluation, but the customer’s EHS team remains responsible for site-specific handling approval.

How Maison Chemical Supports B2B Buyers

At Maison Chemical, I focus on helping customers connect chemical identity with practical sourcing requirements. We can discuss the intended application, quantity range, target specification, packaging preference, destination, and documentation needs before preparing a quotation. This approach helps reduce the risk of comparing materials that share a name but do not meet the same analytical or commercial requirements.

For development and manufacturing inquiries, I recommend providing the required quantity, delivery destination, desired purity, acceptance criteria, and whether a sample or technical review is needed. We can then clarify availability, production planning, export arrangements, and the documents that can accompany the shipment. Any commercial offer should be reviewed against the final specification and approved procurement conditions.

Conclusion: Is CAS 22428-87-1 Suitable for Your Project?

4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is a specialty synthesis intermediate featuring a free hydroxyl group and a protected ketone equivalent. Its principal value is the ability to support controlled functional-group transformations in pharmaceutical research, medicinal chemistry, and broader organic synthesis. The best fit depends on the target route, required purity, acetal stability, downstream deprotection strategy, and documentation standard.

As a next step, define your application, quantity, specification, and delivery schedule, then request the supplier’s identity confirmation, COA, SDS, packaging details, and lead-time information. Contact Maison Chemical with those requirements so I can help evaluate the appropriate material and supply arrangement. A documented technical review before purchase is the most practical way to confirm that this CAS 22428-87-1 intermediate matches your process needs.

The company is the world’s best 4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.