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5 Beneficial Liver Supplements for Dogs | Great Pet Care

Author: Friday

Aug. 11, 2025

5 Beneficial Liver Supplements for Dogs | Great Pet Care

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The liver is a powerful organ that performs many functions, such as filtering out toxins from the blood, metabolizing drugs, and helping with digestion. It can even regenerate itself and continue functioning when many of its cells, called hepatocytes, have suffered damage.

However, factors like old age and exposure to toxins can take a toll on the liver.

Liver supplements for dogs help support the liver when it is not working as well as it used to. The market for these supplements continues to grow, giving dog parents a wide (and sometimes bewildering) variety of liver supplements from which to choose. 

We’re here to help you understand how liver supplements work, why your dog might need one, and what to consider when selecting a liver support supplement for your dog.

How Liver Support Supplements Help Dogs

Dog supplements for liver disease contain active ingredients, such as S-adenosylmethionine (SAMe) and milk thistle, that support the liver in the following functions:

  • Detoxification
  • Protein synthesis
  • Digestion
  • Antioxidant activity 

A normal-functioning liver produces antioxidants that scavenge free radicals, which are substances that damage cells and lead to disease. Liver supplements with antioxidant activity protect liver cells against this damage and promote cellular repair.

Liver supplements also support good overall nutrition by providing additional nutrients like vitamins and probiotics.

Like human supplements, dog supplements for the liver are not curative and do not reverse liver disease. Instead, they support the liver and can help manage the symptoms of liver disease.

Why Your Vet Might Recommend a Dog Liver Supplement

Generally, a liver supplement is unnecessary for a healthy dog with no liver problems. However, veterinarians might recommend liver supplements for:

  • Dogs with medical conditions like liver cancer, liver infection, and liver failure
  • Dogs with digestion issues (the liver plays a key role in digestion)
  • Dogs who eat a homemade diet, because they may lack or be deficient in nutrients necessary for proper liver functioning
  • Senior dogs and dogs on medication

A liver supplement is typically given for long-term liver support, but your veterinarian can determine how long your dog would need to take the supplement.

Only your veterinarian can determine if a liver supplement is appropriate for your dog. 

5 Veterinarian-Prescribed Liver Supplements for Dogs

Searching for liver supplements for dogs online can be overwhelming. We’ve selected a few dog liver supplements to consider and discuss with your veterinarian.

Each of these supplements is taken by mouth and is available in multiple doses according to a dog’s weight.

Denamarin

Denmarin contains two active ingredients: SAMe and silybin. SAMe is produced naturally in the liver and gets converted into glutathione, a chemical that plays important roles in detoxification and antioxidant activity. A liver supplement helps increase SAMe levels that have been reduced because of liver disease. 

SAMe can also support brain health by improving cognition, which is especially important in senior dogs who may be experiencing cognitive decline.

Silybin is an extract of milk thistle, which has antioxidant and anti-inflammatory effects. 

Highlights

  • Contains two active ingredients to support liver health
  • Reduces inflammation
  • Promotes detoxification
  • Antioxidant activity
  • Supports brain health
  • Available as a tablet or a chewable tablet
  • Only available from your veterinarian

Note: There is also a formula called Denamarin Advanced with improved absorption, which means you don’t have to give your pet as many tablets per day compared to the original.

Denosyl

Denosyl contains SAMe as its active ingredient. Like Denamarin, Denosyl supports liver health in several ways, including detoxifying, protecting liver cells, and promoting cellular repair. Denosyl can also support healthy brain functioning.

Highlights

  • SAMe is the active ingredient
  • Helps with detoxification 
  • Antioxidant activity 
  • Supports cognitive function
  • Only available through your veterinarian

Vetri SAMe Tablets

Vetri SAMe tablets combine SAMe and glutathione to promote detoxification and carry out antioxidant activity. They have a special coating (enteric coating) to protect them from stomach acid, ensuring that they make it to the small intestine and are fully absorbed.

Highlights

  • Contains SAMe and glutathione as its active ingredients
  • Promotes detoxification 
  • Antioxidant effects
  • Enteric coating to maximize absorption in the small intestine
  • Has earned the National Animal Supplement Council (NASC) seal of approval
  • Ideal for dogs with sensitive stomachs
  • Should be given on an empty stomach, about one hour before mealtime 

Vetri-Liver Support Soft Chew for Dogs

Vetri-Liver Support soft chews for dogs have an appealing chicken flavor and contain 15 ingredients, including glutathione and vitamin E, that work in two phases to support liver health. Phase 1 converts toxins into less dangerous substances, and phase 2 makes these substances water soluble so the body can easily eliminate them. These ingredients also support fat metabolism and antioxidant activity.

Highlights

  • Contains 15 active ingredients that support liver health
  • Helps with detoxification and fat metabolism
  • Antioxidant effects 
  • Has earned the NASC seal of approval

Rx Vitamins Hepato Support Capsules

Rx Vitamins Hepato Support capsules contain silymarin, which is extracted from the seeds of the milk thistle plant, plus B vitamins and alpha lipoic acid to help support normal liver function. Silymarin boosts glutathione levels and helps protect the liver from toxins. One capsule contains 100 milligrams of milk thistle extract. If you have trouble giving your dog pills, it is also available in liquid format.

Highlights

  • Contains several active ingredients to support liver function
  • Promotes detoxification
  • Antioxidant activity
  • Has earned the NASC seal of approval

Dog Liver Support Supplements: Tips and Safety

Here are some things to consider before giving your dog a liver supplement:

Talk with your veterinarian. Your veterinarian will be your best source of information about liver supplements for dogs. They will be able to determine if your dog needs a liver supplement and advise you on which liver supplement would be best for your dog. 

Consider your dog’s current medications. Liver supplements may interact with other medications and potentially decrease a medication’s effect. Discuss your dog’s medication history with your veterinarian.

Consider cost. Liver supplements can be expensive, especially when given long-term. Your veterinarian can help you identify budget-friendly liver supplements and advise you on how long your dog may need the supplement.

Follow label instructions. The label contains key information on dosing and storage. Please read this information closely to ensure you give your dog the correct dose according to their weight and safely store the product away from pets and children. 

Identify the lot number. Make sure the supplement has a lot number on its label. The lot number indicates that the product has undergone strict quality control to ensure its safety. 

Research the manufacturer. Don’t believe the marketing hype. Research the manufacturer by reading through their website or contacting them by to determine whether they put their products through independent safety and efficacy testing.

Liver Supplements for Dogs: Everything You Need to Know

Liver health is crucial for dogs, as the liver plays a vital role in detoxifying the body, metabolizing nutrients, and supporting overall health. 

Liver supplements can be beneficial for maintaining and improving liver function in dogs, particularly those with liver disease or other health conditions. 

In this comprehensive guide, we'll explore everything you need to know about liver supplements for dogs, including their benefits, types, key ingredients, and tips for choosing the right supplement for your furry friend.

The Importance of the Liver

The liver is one of the most important organs in a dog's body. It is responsible for a variety of critical functions that keep your pet healthy. The liver filters toxins from the blood, ensuring that harmful substances are removed from the body. 

Additionally, it metabolizes proteins, fats, and carbohydrates, playing a key role in digestion and energy production. The liver also produces bile, which aids in the digestion of fats, and stores essential vitamins and minerals. 

Furthermore, the liver supports the immune system by producing proteins vital for immune responses. Given its multifaceted role, maintaining liver health is essential for your dog's overall well-being.

Common Liver Problems in Dogs

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Dogs can suffer from various liver conditions, each presenting its own challenges. Hepatitis, for example, is an inflammation of the liver often caused by infections, toxins, or autoimmune diseases. 

Liver cirrhosis involves the scarring of liver tissue due to chronic damage, which can impair liver function. Liver tumors, which can be benign or malignant, pose significant health risks depending on their nature and location. 

Hepatic lipidosis, or fat accumulation in the liver, is commonly seen in overweight dogs and can lead to severe health issues. Recognizing the signs of liver disease—such as jaundice (yellowing of the skin and eyes), lethargy, loss of appetite, and vomiting—can help you seek timely veterinary care and improve your dog's prognosis.

Benefits of Liver Supplements for Dogs

Liver supplements can provide numerous benefits, particularly for dogs with compromised liver function. These liver supplements often contain ingredients that aid in detoxification, helping the liver remove toxins more efficiently. They also have anti-inflammatory properties, reducing liver inflammation and the associated pain. 

Moreover, liver supplements offer antioxidant support, protecting liver cells from oxidative damage caused by free radicals. They provide essential nutrients that support overall liver health and function. 

Additionally, by enhancing the liver's ability to process and remove toxins, these supplements can give a significant boost to the immune system, contributing to your dog's overall health.

Types of Liver Supplements for Dogs

1. Supplements

Liver supplements are popular for their natural ingredients, known for supporting liver health. 

Milk thistle is a common component, containing silymarin, which has potent antioxidant and anti-inflammatory effects. 

Dandelion root is another herb often used in liver supplements; it supports liver detoxification and bile production, aiding digestion. 

Turmeric, with its active compound curcumin, offers anti-inflammatory and antioxidant benefits, helping to protect liver cells from damage and reduce inflammation. 

Supplements made from these herbs can be effective in maintaining liver health, particularly when used as part of a comprehensive health plan.

2. Nutritional Supplements

Nutritional supplements provide essential vitamins, minerals, and other nutrients that support liver health. Vitamin E is a powerful antioxidant that protects liver cells from oxidative stress. 

Vitamin B complex is crucial for liver metabolism and overall health, supporting various enzymatic functions within the liver. Zinc plays a vital role in liver enzyme function, aiding in the detoxification process and supporting the immune system. 

These supplements can help fill nutritional gaps and support the liver's natural functions, promoting overall health and well-being.

3. Prescription Diets

For dogs with severe liver conditions, veterinarians may prescribe specific medications or supplements.

Denamarin, a combination of SAMe and silymarin, provides enhanced liver support, promoting cell regeneration and protecting against damage. Ursodiol, a bile acid, helps improve liver function by reducing bile duct inflammation and aiding in the breakdown of fats. 

These medications are typically used under veterinary supervision to manage serious liver diseases and improve the dog's quality of life.

Also Read: Best Hepatic Foods for Dogs

Choosing the Right Liver Supplement for Your Dog

1. Consult Your Veterinarian

Before starting any liver supplement, it is essential to consult with your veterinarian. They can diagnose any underlying liver conditions and recommend the most appropriate supplement based on your dog's specific needs. 

Your veterinarian can also monitor your dog's progress and adjust the treatment plan as necessary, ensuring the best possible outcome for your pet.

2. Consider Your Dog's Specific Needs

Different dogs have different needs based on factors such as age, breed, and health status. Senior dogs, for example, may benefit from supplements with higher antioxidant content to support aging liver function. Some breeds are more prone to liver issues and may require specific supplements tailored to their needs. Dogs with existing liver conditions may need prescription medications or specialized supplements to manage their condition effectively. Considering your dog's specific needs can help you choose the most appropriate liver supplement and support overall health.

3. Quality and Safety

Choosing high-quality supplements from reputable manufacturers is crucial for ensuring safety and efficacy. 

Look for products made with high-quality, natural ingredients that have undergone third-party testing for purity and potency. 

Positive reviews from other pet owners and veterinarians can also provide valuable insights into the effectiveness and safety of the supplement. By selecting a high-quality product, you can ensure that your dog receives the best possible support for their liver health.

4. Dosage and Administration

Following the dosage instructions provided by your veterinarian or the supplement manufacturer is essential for ensuring the supplement's effectiveness. Some supplements come in different forms, such as tablets, powders, or liquids, each with its own administration method. 

Tablets may be easy to dose but can be challenging to administer to picky eaters. Powders can be mixed with food for easier administration, while liquids are often more palatable and easier to administer. Choosing the right form and following the recommended dosage can help ensure that your dog receives the full benefits of the supplement.

Conclusion

Maintaining your dog's liver health is crucial for their overall well-being. Liver supplements can provide valuable support, particularly for dogs with liver conditions or those at risk. 

By understanding the benefits, types, and key ingredients of liver supplements, and by working closely with your veterinarian, you can make informed decisions to support your dog's liver health. 

Remember, every dog is unique, so what works for one may not work for another. Always prioritize your dog's specific needs and consult with your veterinarian to ensure the best care possible.

If you have any query regarding your pet, feel free to reach us at the Cessna Pet Store. Here, you can easily find every kind of dog prescription diet, along with vet checkup under one roof.

Thank you for reading!

Are you interested in learning more about liver support chews for dogs cats? Contact us today to secure an expert consultation!

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